TICAM2 and IL1RAP

Number of citations of the paper that reports this interaction (PubMedID 12721283)
0

Data Source:
HPRD (in vitro)

		TICAM2	IL1RAP
Description		TIR domain containing adaptor molecule 2	interleukin 1 receptor accessory protein
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GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Endosome Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection	Extracellular Region Plasma Membrane Cell Surface Membrane Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Signaling Adaptor Activity Molecular Adaptor Activity	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Coreceptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Immune System Process Phagocytosis Inflammatory Response Signal Transduction Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Response To Other Organism Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Immune System Process Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)	Blood protein levels ( 30072576) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		21 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 LVRN MEF2C MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6	22 interacting genes: AP2M1 CCNI FXR1 IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		353376	3556
HPRD ID		16313	04021
Ensembl ID		ENSG00000243414	ENSG00000196083
Uniprot IDs		Q86XR7	A8K6K4 Q9NPH3
PDB IDs		2M1W 9DKI 9DLG	3O4O 4DEP 7FCC
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Immune Response-activating Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Defense Response Positive Regulation Of Immune Response Regulation Of Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Immune Response Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll Signaling Pathway Regulation Of Interferon-beta Production Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Regulation Of Interleukin-6 Production Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Response To Other Organism Endosome Membrane Positive Regulation Of Interferon-beta Production	Regulation Of Cytokine Production Cytokine-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Multicellular Organismal Process Regulation Of Canonical NF-kappaB Signal Transduction Immune Response Positive Regulation Of Cytokine Production Inflammatory Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Interleukin-1 Receptor Activity Immune System Process Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Interleukin-1 Receptor Binding Regulation Of Defense Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of T-helper 1 Type Immune Response Response To Lipopolysaccharide Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Cytokine Production Involved In Inflammatory Response Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Glutamatergic Synapse Positive Regulation Of Cytokine Production Involved In Immune Response Response To Peptide Fever Generation Positive Regulation Of Transport Positive Regulation Of Interleukin-6 Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of Multicellular Organismal Process
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