ACO2 and CD244

		ACO2	CD244
Description		aconitase 2	CD244 molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Plasma Membrane External Side Of Plasma Membrane Membrane Membrane Raft
	Molecular Function	Aconitate Hydratase Activity Iron Ion Binding Lyase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding Signaling Receptor Activity MHC Class I Protein Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Citrate Metabolic Process	Adaptive Immune Response Natural Killer Cell Activation Involved In Immune Response Immune System Process Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Innate Immune Response Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Granzyme B Production
Pathways		Mitochondrial protein import Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle	Cell surface interactions at the vascular wall
Drugs		Isocitric Acid 4-Hydroxy-Aconitate Ion Alpha-Methylisocitric Acid Aconitate Ion Tricarballylic acid
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 32296059) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: APP ATXN1L C5AR2 CD244 CDC42 LINC00632 RNF10 SUMO4	11 interacting genes: ACO2 ARHGEF7 CD247 CD48 LAT OLFML2B PCGF1 PDGFRA SH2D1A SH2D1B TOMM40L
Entrez ID		50	51744
HPRD ID		00012	16121
Ensembl ID		ENSG00000100412	ENSG00000122223
Uniprot IDs		Q99798	Q9BZW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Regulation Of Type II Interferon Production Cell Activation Involved In Immune Response Dendrite Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Regulation Of Interleukin-6 Production Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Positive Regulation Of Type II Interferon Production Positive Regulation Of Small Molecule Metabolic Process Learning Lipoprotein Particle Memory Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Apical Part Of Cell Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Complement Component C5a Receptor Activity Regulation Of Interleukin-8 Production Complement Component C5a Signaling Pathway	Cell Activation Leukocyte Activation Adaptive Immune Response Lymphocyte Activation Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Immune Response Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Platelet-derived Growth Factor Alpha-receptor Activity Negative Regulation Of Microtubule Nucleation Aconitate Hydratase Activity Fc-gamma Receptor III Complex Gamma-delta T Cell Receptor Complex Immune Effector Process Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Receptor-ligand Complex TCR Signalosome
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