ORC1 and TMEM97

		ORC1	TMEM97
Description		origin recognition complex subunit 1	transmembrane protein 97
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Nucleus Lysosome Endoplasmic Reticulum Rough Endoplasmic Reticulum Plasma Membrane Membrane Rough Endoplasmic Reticulum Membrane Nuclear Membrane
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding	Protein Binding Oxysterol Binding Cholesterol Binding
	Biological Process	DNA Replication DNA Replication Initiation Mitotic DNA Replication Checkpoint Signaling	Regulation Of Cell Growth Regulation Of Intracellular Lipid Transport Regulation Of Intracellular Cholesterol Transport Cholesterol Homeostasis Positive Regulation Of Wound Healing Positive Regulation Of Lipoprotein Transport
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS			Advanced age-related macular degeneration ( 26691988) Osteoprotegerin levels ( 25080503)
Interacting Genes		26 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 H4C1 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RFWD3 RPA2 SKP2 TMEM97 XPO1	75 interacting genes: ADCYAP1R1 APP AQP12B AQP2 AQP6 ARL13B ASZ1 ATP6AP2 BCL2L13 BIK CD53 CD74 CD79A CGRRF1 CLDN7 CLSTN3 CPLX4 CRLF3 EBP ERAL1 ERGIC3 FAM209A FFAR2 FKBP7 FRMD3 FXYD3 GJA8 GJB3 GJB5 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LEUTX LHFPL5 LIME1 LRRC59 MFF MRM1 MTIF3 MUC1 NDUFAF1 NDUFAF2 NEMP1 ORC1 PDCD1LG2 PDZK1IP1 PLP1 POLDIP2 PSCA REEP1 RHCG RNF167 RNF170 SAR1A SGPL1 SLC10A1 SLC14A1 SLC14A2 SLC18A1 SLC35H1 SPINT1 SSMEM1 TADA1 TBC1D29P TMEM106C TMEM14B TMEM45B TMEM52B TMEM79 TMX2 UTP4 VSIR
Entrez ID		4998	27346
HPRD ID		03544	14343
Ensembl ID		ENSG00000085840	ENSG00000109084
Uniprot IDs		B7Z8H0 Q13415 Q96F82	Q5BJF2
PDB IDs		5UJ7 5UJM 6P3W 7CTF 7CTG 7JPO 7JPP 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process CMG Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Nuclear Origin Of Replication Recognition Complex Recombinational Repair Nucleoplasm MCM Complex DNA Repair Double-strand Break Repair DNA Recombination Origin Recognition Complex Single-stranded DNA Binding DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromosome Macromolecule Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Process Positive Regulation Of DNA-templated DNA Replication Nucleus Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of Nuclear Cell Cycle DNA Replication Cellular Response To Stress Helicase Activity Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling DNA Replication Preinitiation Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process DNA Replication Checkpoint Signaling	Membrane Water Transport One-carbon Compound Transport Fluid Transport Protein Binding Water Channel Activity Endoplasmic Reticulum Membrane Connexin Complex Endoplasmic Reticulum Gap Junction Channel Activity Plasma Membrane B Cell Receptor Complex Water Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Mitochondrial Membrane Gap Junction Urea Transmembrane Transporter Activity Transmembrane Transport
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