ORC1 and CDC6

Number of citations of the paper that reports this interaction (PubMedID 12912926)
46

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		ORC1	CDC6
Description		origin recognition complex subunit 1	cell division cycle 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding	Nucleotide Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Protein Serine/threonine Kinase Binding
	Biological Process	DNA Replication DNA Replication Initiation Mitotic DNA Replication Checkpoint Signaling	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription	Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS			Asthma ( 31619474)
Interacting Genes		26 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 H4C1 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RFWD3 RPA2 SKP2 TMEM97 XPO1	41 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 DSC2 FAM13A-AS1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PLK1 PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBC UBE2K UBR1
Entrez ID		4998	990
HPRD ID		03544	04022
Ensembl ID		ENSG00000085840	ENSG00000094804
Uniprot IDs		B7Z8H0 Q13415 Q96F82	Q99741
PDB IDs		5UJ7 5UJM 6P3W 7CTF 7CTG 7JPO 7JPP 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F	2CCH 2CCI 4I5L 4I5N 8HT7 8RWV 8S0E
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process CMG Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Nuclear Origin Of Replication Recognition Complex Recombinational Repair Nucleoplasm MCM Complex DNA Repair Double-strand Break Repair DNA Recombination Origin Recognition Complex Single-stranded DNA Binding DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromosome Macromolecule Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Process Positive Regulation Of DNA-templated DNA Replication Nucleus Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of Nuclear Cell Cycle DNA Replication Cellular Response To Stress Helicase Activity Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling DNA Replication Preinitiation Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process DNA Replication Checkpoint Signaling	DNA Replication Initiation DNA Replication Regulation Of DNA Replication Nucleoplasm DNA Metabolic Process DNA Replication Origin Binding Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Cell Cycle G2/M Phase Transition Protein Modification Process Positive Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Primary Metabolic Process Chromosome Positive Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fibroblast Proliferation Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Nucleolus
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