GFRA1 and RET

Number of citations of the paper that reports this interaction (PubMedID 10829012)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		GFRA1	RET
Description		GDNF family receptor alpha 1	ret proto-oncogene
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GO Annotations	Cellular Component	Extracellular Space Endosome Multivesicular Body Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Axon Neuronal Cell Body Receptor Complex Extracellular Exosome Side Of Membrane Plasma Membrane Protein Complex	Endosome Plasma Membrane Endosome Membrane Membrane Axon Receptor Complex Plasma Membrane Protein Complex
	Molecular Function	Neurotrophin Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity
	Biological Process	Kidney Development Cell Surface Receptor Signaling Pathway Nervous System Development Male Gonad Development Cell Migration Neuron Differentiation Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Posterior Midgut Development Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs GDF15-GFRAL Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling Formation of the ureteric bud	RAF/MAP kinase cascade RET signaling NPAS4 regulates expression of target genes Formation of the nephric duct Formation of the ureteric bud
Drugs			Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib
Diseases			Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Thyroid cancer Renal agenesis and Renal adysplasia
GWAS		Blood protein levels ( 30072576) Delirium ( 29631748) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Malaria ( 31844061) Migraine without aura ( 28952330) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)	Blood protein levels ( 30072576) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 25310821 27702942 29379196 30031151) Smoking behaviour (cigarettes smoked per day) ( 31089300)
Interacting Genes		5 interacting genes: GDNF NCAM1 NRTN RET SOCS3	46 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SNCA SRC STAT3 TLN1
Entrez ID		2674	5979
HPRD ID		03291	01266
Ensembl ID		ENSG00000151892	ENSG00000165731
Uniprot IDs		B7Z856 P56159	A0A087WWB1 A0AAQ5BH28 B4DGX8 P07949
PDB IDs		6Q2N	2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG 7DU8 7DU9 7DUA 7JU5 7JU6 7NZN 7RUN
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Binding Neural Crest Cell Migration Regulation Of Semaphorin-plexin Signaling Pathway Mesenchymal Cell Migration Neuron Projection Development Ameboidal-type Cell Migration Enteric Nervous System Development Commissural Neuron Axon Guidance Embryonic Epithelial Tube Formation Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Epithelial Tube Formation Metanephros Development Regulation Of Kidney Development Ureteric Bud Development Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesonephric Epithelium Development Mesonephric Tubule Development Cell Projection Organization Receptor Tyrosine Kinase Binding Tissue Morphogenesis Kidney Epithelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Tube Formation Posterior Midgut Development Morphogenesis Of A Branching Structure Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Factor Activity Morphogenesis Of A Branching Epithelium Cell Surface Receptor Signaling Pathway Chemoattraction Of Axon Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Kidney Development Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Ureter Maturation Autonomic Nervous System Development Ureteric Bud Formation Cell Migration Dorsal Spinal Cord Development GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Intracellular Signal Transduction Regulation Of Signal Transduction Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Signal Transduction ERBB2 Signaling Pathway Plasma Membrane Ephrin Receptor Binding Regulation Of MAPK Cascade Focal Adhesion Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Cytoplasm MAP Kinase Activity Negative Regulation Of Immune System Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Domain Specific Binding Schwann Cell Development Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Migration Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Response To Epidermal Growth Factor Positive Regulation Of Cell Motility Regulation Of Immune System Process Negative Regulation Of Signal Transduction Positive Regulation Of Locomotion Stress-activated MAPK Cascade Insulin Receptor Binding Regulation Of Locomotion
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