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NEDD4 and RET
Number of citations of the paper that reports this interaction (PubMedID
37659079
)
85
Data Source:
BioGRID
(pull down, affinity chromatography technology, affinity chromatography technology)
NEDD4
RET
Description
NEDD4 E3 ubiquitin protein ligase
ret proto-oncogene
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Apicolateral Plasma Membrane
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Cytosol
Endosome
Plasma Membrane
Endosome Membrane
Membrane
Axon
Receptor Complex
Plasma Membrane Protein Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Channel Inhibitor Activity
Transferase Activity
Potassium Channel Inhibitor Activity
Sodium Channel Inhibitor Activity
Enzyme Binding
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ionotropic Glutamate Receptor Binding
Ubiquitin Binding
Transmembrane Transporter Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Signaling Receptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Adaptive Immune Response
Outflow Tract Morphogenesis
Endocardial Cushion Development
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Targeting To Lysosome
Sodium Ion Transport
Immune Response
DNA Damage Response
Lysosomal Transport
Nervous System Development
Neuromuscular Junction Development
Regulation Of Cell Communication
Negative Regulation Of Sodium Ion Transport
Regulation Of Macroautophagy
Protein Ubiquitination
Regulation Of Signaling
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
T Cell Activation
Regulation Of Protein Catabolic Process
Regulation Of Membrane Potential
Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Formation Of Structure Involved In A Symbiotic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Viral Budding
Positive Regulation Of Nucleocytoplasmic Transport
Blood Vessel Morphogenesis
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Establishment Of Localization In Cell
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Biological Quality
Protein K63-linked Ubiquitination
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
MAPK Cascade
Ureteric Bud Development
Neural Crest Cell Migration
Embryonic Epithelial Tube Formation
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Neuron Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Axon Guidance
Posterior Midgut Development
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Regulation Of Cell Adhesion
Neuron Differentiation
Positive Regulation Of Cell Migration
Membrane Protein Proteolysis
Positive Regulation Of Cell Adhesion Mediated By Integrin
Ureter Maturation
Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Neuron Maturation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Size
Positive Regulation Of DNA-templated Transcription
Response To Pain
Enteric Nervous System Development
Regulation Of Axonogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Peyer's Patch Morphogenesis
Cellular Response To Retinoic Acid
Positive Regulation Of Metanephric Glomerulus Development
Lymphocyte Migration Into Lymphoid Organs
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
RAF/MAP kinase cascade
RET signaling
NPAS4 regulates expression of target genes
Formation of the nephric duct
Formation of the ureteric bud
Drugs
Sorafenib
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Vandetanib
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Fostamatinib
Amuvatinib
Selpercatinib
Pralsetinib
Diseases
Congenital central hypoventilation syndrome (CCHS)
Hirschsprung disease (HD)
Thyroid cancer
Renal agenesis and Renal adysplasia
GWAS
Appendicular lean mass (
33097823
)
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
24292274
28165464
)
Dupuytren's disease (
28886342
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Joint mobility (Beighton score) (
27182965
)
Keloid (
20711176
)
Refractive error (
32231278
)
Blood protein levels (
30072576
)
Cannabis dependence symptom count (
27028160
)
Hirschsprung disease (
19196962
25310821
27702942
29379196
30031151
)
Smoking behaviour (cigarettes smoked per day) (
31089300
)
Interacting Genes
282 interacting genes:
ABCB1
ABL1
ABL2
ADRB2
AK6
AKT1
AKT3
AMOT
AMOTL1
AMPD2
ANK3
ANKRD13D
ANXA13
AP1G2
ARID1A
ASPSCR1
AURKC
BAIAP2
BAIAP2L1
BIRC6
BMPR1A
C15orf62
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDIP1
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CRTC2
CUEDC1
DAZAP2
DCUN1D1
DDN
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EGR1
ENTREP1
EP300
EPHA5
EPRS1
EPS15
ERBB3
ERBB4
ERMN
ERRFI1
ESS2
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FOXJ3
FYN
GABARAP
GABARAPL1
GABARAPL2
GBA1
GFUS
GJA1
GRB10
GRIN2A
GRK4
GRK7
H3-3A
HGS
HMCES
HMGCL
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
HRAS
IFITM3
IGF1R
IL1B
IRS1
IRS2
JHY
JUN
KCNAB1
KCNAB2
KCNJ16
KIFC3
KLF5
KRAS
LATS1
LDLRAD3
LDLRAD4
LINC01198
LITAF
LUC7L2
MAML2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MS4A10
MTMR4
MYCN
MYCT1
MYO15B
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NRAS
NSRP1
NUDT21
NUMB
PARP16
PAX7
PDGFRB
PIP4P2
PIP5K1A
PIP5K1C
PKN2
PLK1
PLK2
PMEPA1
POLR1C
POLR2A
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRR7
PRRG2
PRRG4
PSMD4
PTEN
PYM1
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RBM14
RET
RFT1
RHBDD1
RHBDD2
RNF11
RNF38
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUVBL1
SAAL1
SAMSN1
SAV1
SCAMP3
SCN10A
SCN1A
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPTIN9
SFTPC
SGK1
SGK2
SH3KBP1
SHISA6
SHTN1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SQSTM1
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
STRIP2
SULF1
SYK
SYNPO2
SYT1
TAF1B
TBC1D7
TCEANC
TCP11L1
TEAD2
TGFB1I1
THOC1
THRAP3
TMEM139
TMEM252
TMEM51
TNIK
TOM1
TOM1L2
TP53BP2
TP63
TP73
TRERF1
TRIM44
TRIM52
TRPV6
TTYH2
TTYH3
TULP4
TUSC2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2L6
UBE2M
UBOX5
URI1
UVRAG
VDAC2
VDAC3
WBP1
WBP2
WEE1
YES1
YOD1
ZC3H14
46 interacting genes:
AKAP5
CBL
CBLB
CRK
DOK1
DOK2
DOK3
DOK4
DOK5
DOK6
DUSP26
ERBB2
FBXO7
FRS2
GAB1
GDNF
GFRA1
GRB10
GRB2
GRB7
IKBKG
LRRK1
MAPK1
MAPK14
MAPK3
MAPK8
NEDD4
NOTCH2NLA
NOTCH3
NRTN
PDLIM7
PIK3R1
PLCG1
PRKAR2A
PTK2
PTPN11
PTPRA
PTPRF
PTPRR
SHC1
SHC3
SHC4
SNCA
SRC
STAT3
TLN1
Entrez ID
4734
5979
HPRD ID
03786
01266
Ensembl ID
ENSG00000069869
ENSG00000165731
Uniprot IDs
P46934
A0A087WWB1
A0AAQ5BH28
B4DGX8
P07949
PDB IDs
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
4N7F
4N7H
5AHT
5C7J
5C91
2IVS
2IVT
2IVU
2IVV
2X2K
2X2L
2X2M
2X2U
4CKI
4CKJ
4UX8
5AMN
5FM2
5FM3
6FEK
6GL7
6I82
6I83
6NE7
6NEC
6NJA
6Q2J
6Q2N
6Q2O
6Q2R
6Q2S
6VHG
7DU8
7DU9
7DUA
7JU5
7JU6
7NZN
7RUN
Enriched GO Terms of Interacting Partners
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Protein Kinase Activity
Kinase Activity
Protein Phosphorylation
Intracellular Signal Transduction
ATP Binding
Nucleotide Binding
Phosphorylation
WW Domain Binding
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Transferase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Serine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Protein Autophosphorylation
Signal Transduction
Cytoplasm
Regulation Of Protein Modification Process
Protein Modification Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
MAPK Cascade
Positive Regulation Of Metabolic Process
Peptidyl-tyrosine Phosphorylation
Macromolecule Metabolic Process
Positive Regulation Of Cell Communication
Apoptotic Process
Intracellular Signaling Cassette
Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cytosol
Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Programmed Cell Death
Cell Surface Receptor Signaling Pathway
Cell Death
Regulation Of Apoptotic Process
Nucleoplasm
Regulation Of Biological Quality
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Projection Organization
Response To Growth Factor
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Motility
Regulation Of Locomotion
Regulation Of Cell Communication
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Receptor Tyrosine Kinase Binding
Intracellular Signal Transduction
Regulation Of Signal Transduction
Neurotrophin TRKA Receptor Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytosol
Insulin Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Intracellular Signaling Cassette
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Response To Growth Factor
Positive Regulation Of Signal Transduction
ERBB2 Signaling Pathway
Plasma Membrane
Ephrin Receptor Binding
Regulation Of MAPK Cascade
Focal Adhesion
Regulation Of Cell Adhesion
Cellular Response To Growth Factor Stimulus
Cytoplasm
MAP Kinase Activity
Negative Regulation Of Immune System Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Domain Specific Binding
Schwann Cell Development
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Cell Migration
Protein Phosphatase Binding
Protein Tyrosine Phosphatase Activity
Response To Epidermal Growth Factor
Positive Regulation Of Cell Motility
Regulation Of Immune System Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Stress-activated MAPK Cascade
Insulin Receptor Binding
Regulation Of Locomotion
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