NEDD4 and IL1B

Number of citations of the paper that reports this interaction (PubMedID 32597834)
85

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		NEDD4	IL1B
Description		NEDD4 E3 ubiquitin protein ligase	interleukin 1 beta
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Apicolateral Plasma Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol	Extracellular Region Extracellular Space Cytoplasm Lysosome Cytosol Secretory Granule Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Channel Inhibitor Activity Transferase Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ionotropic Glutamate Receptor Binding Ubiquitin Binding Transmembrane Transporter Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding	Cytokine Activity Interleukin-1 Receptor Binding Integrin Binding Protein Binding Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Targeting To Lysosome Sodium Ion Transport Immune Response DNA Damage Response Lysosomal Transport Nervous System Development Neuromuscular Junction Development Regulation Of Cell Communication Negative Regulation Of Sodium Ion Transport Regulation Of Macroautophagy Protein Ubiquitination Regulation Of Signaling Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV T Cell Activation Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Formation Of Structure Involved In A Symbiotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Viral Budding Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Biological Quality Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Fever Generation Positive Regulation Of Cytokine Production Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction JNK Cascade Cell-cell Signaling Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Carbohydrate Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of D-glucose Transmembrane Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Ectopic Germ Cell Programmed Cell Death Positive Regulation Of T Cell Proliferation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Astrocyte Activation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Negative Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Migration Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Interleukin-17 Positive Regulation Of Neuroinflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Endothelial Barrier Regulation Of Secretion By Cell Negative Regulation Of Gap Junction Assembly Positive Regulation Of Tight Junction Disassembly Positive Regulation Of T-helper 1 Cell Cytokine Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-1 processing Pyroptosis CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs			Donepezil Minocycline VP025 Gallium nitrate Talmapimod Etiprednol dicloacetate VX-702 VX-765 Andrographolide Canakinumab Rilonacept Foreskin keratinocyte (neonatal) Binimetinib Gevokizumab Dilmapimod
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 24292274 28165464) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Joint mobility (Beighton score) ( 27182965) Keloid ( 20711176) Refractive error ( 32231278)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758) Dysmenorrheic pain severity ( 29855537) Gestational age at birth (child effect) ( 31477735) Post-term birth ( 31477735)
Interacting Genes		282 interacting genes: ABCB1 ABL1 ABL2 ADRB2 AK6 AKT1 AKT3 AMOT AMOTL1 AMPD2 ANK3 ANKRD13D ANXA13 AP1G2 ARID1A ASPSCR1 AURKC BAIAP2 BAIAP2L1 BIRC6 BMPR1A C15orf62 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDIP1 CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CRTC2 CUEDC1 DAZAP2 DCUN1D1 DDN DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EGR1 ENTREP1 EP300 EPHA5 EPRS1 EPS15 ERBB3 ERBB4 ERMN ERRFI1 ESS2 FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FOXJ3 FYN GABARAP GABARAPL1 GABARAPL2 GBA1 GFUS GJA1 GRB10 GRIN2A GRK4 GRK7 H3-3A HGS HMCES HMGCL HNRNPK HNRNPL HNRNPU HNRNPUL1 HRAS IFITM3 IGF1R IL1B IRS1 IRS2 JHY JUN KCNAB1 KCNAB2 KCNJ16 KIFC3 KLF5 KRAS LATS1 LDLRAD3 LDLRAD4 LINC01198 LITAF LUC7L2 MAML2 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MS4A10 MTMR4 MYCN MYCT1 MYO15B N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NRAS NSRP1 NUDT21 NUMB PARP16 PAX7 PDGFRB PIP4P2 PIP5K1A PIP5K1C PKN2 PLK1 PLK2 PMEPA1 POLR1C POLR2A POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRR7 PRRG2 PRRG4 PSMD4 PTEN PYM1 RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RBM14 RET RFT1 RHBDD1 RHBDD2 RNF11 RNF38 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SAV1 SCAMP3 SCN10A SCN1A SCN5A SCNN1A SCNN1B SCNN1G SEPTIN9 SFTPC SGK1 SGK2 SH3KBP1 SHISA6 SHTN1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SQSTM1 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 STRIP2 SULF1 SYK SYNPO2 SYT1 TAF1B TBC1D7 TCEANC TCP11L1 TEAD2 TGFB1I1 THOC1 THRAP3 TMEM139 TMEM252 TMEM51 TNIK TOM1 TOM1L2 TP53BP2 TP63 TP73 TRERF1 TRIM44 TRIM52 TRPV6 TTYH2 TTYH3 TULP4 TUSC2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2L6 UBE2M UBOX5 URI1 UVRAG VDAC2 VDAC3 WBP1 WBP2 WEE1 YES1 YOD1 ZC3H14	18 interacting genes: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FBXL2 FURIN FYN IL1R1 IL1R2 IL1RAP LYN MMP2 NEDD4 PRTN3 SP1
Entrez ID		4734	3553
HPRD ID		03786	00985
Ensembl ID		ENSG00000069869	ENSG00000125538
Uniprot IDs		P46934	P01584
PDB IDs		2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H 5AHT 5C7J 5C91	1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5BVP 5I1B 5MVZ 5R7W 5R85 5R86 5R87 5R88 5R89 5R8A 5R8B 5R8C 5R8D 5R8E 5R8F 5R8G 5R8H 5R8I 5R8J 5R8K 5R8L 5R8M 5R8N 5R8O 5R8P 5R8Q 6I1B 6Y8I 6Y8M 7CHY 7CHZ 7I1B 7Z4T 8C3U 8RYK 8RYS 8RZB 9ILB
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Phosphorylation Intracellular Signal Transduction ATP Binding Nucleotide Binding Phosphorylation WW Domain Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Transferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Serine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Protein Autophosphorylation Signal Transduction Cytoplasm Regulation Of Protein Modification Process Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process MAPK Cascade Positive Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Macromolecule Metabolic Process Positive Regulation Of Cell Communication Apoptotic Process Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Positive Regulation Of Signaling Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Programmed Cell Death Cell Surface Receptor Signaling Pathway Cell Death Regulation Of Apoptotic Process Nucleoplasm Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Projection Organization Response To Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Communication	Enzyme Binding Regulation Of Inflammatory Response Regulation Of Defense Response Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Cytokine Precursor Processing Interleukin-1-mediated Signaling Pathway Interleukin-1 Receptor Activity Immune System Process Interleukin-1 Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Proteolysis Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Cellular Response To Amyloid-beta Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Response To Stress Protein Processing Positive Regulation Of Signal Transduction Immune Response Positive Regulation Of Multicellular Organismal Process Endopeptidase Activity Membrane Raft Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ephrin Receptor Binding Protein Metabolic Process Peptidase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-1 Production Positive Regulation Of Intracellular Signal Transduction Collagen Catabolic Process Growth Factor Receptor Binding Signaling Receptor Ligand Precursor Processing Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Protein Maturation NLRP1 Inflammasome Complex Extracellular Matrix Disassembly Serine-type Endopeptidase Activity Glutamate Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Metal Ion Transport Heparan Sulfate Binding
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