NEDD4 and PTEN

Number of citations of the paper that reports this interaction (PubMedID 33712741)
68

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		NEDD4	PTEN
Description		NEDD4 E3 ubiquitin protein ligase	phosphatase and tensin homolog
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Apicolateral Plasma Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Apical Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Channel Inhibitor Activity Transferase Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ionotropic Glutamate Receptor Binding Ubiquitin Binding Transmembrane Transporter Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding	Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity Enzyme Binding PDZ Domain Binding Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Identical Protein Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity Molecular Function Inhibitor Activity Ubiquitin-specific Protease Binding Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Targeting To Lysosome Sodium Ion Transport Immune Response DNA Damage Response Lysosomal Transport Nervous System Development Neuromuscular Junction Development Regulation Of Cell Communication Negative Regulation Of Sodium Ion Transport Regulation Of Macroautophagy Protein Ubiquitination Regulation Of Signaling Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV T Cell Activation Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Formation Of Structure Involved In A Symbiotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Viral Budding Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Biological Quality Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Osteoblast Differentiation Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Apoptotic Process Spindle Assembly Involved In Female Meiosis Neuron-neuron Synaptic Transmission Nervous System Development Synapse Assembly Central Nervous System Development Heart Development Learning Or Memory Locomotory Behavior Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Cell Migration Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Migration Adult Behavior Regulation Of Protein Stability Central Nervous System Myelin Maintenance Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organismal Response To Stress Social Behavior Maternal Behavior Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Locomotor Rhythm Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Organ Growth Phosphatidylinositol Dephosphorylation Forebrain Morphogenesis Cell Motility Negative Regulation Of Axonogenesis Protein Stabilization Negative Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Keratinocyte Migration Regulation Of Cell Cycle Negative Regulation Of Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Rhythmic Synaptic Transmission Synapse Maturation Prepulse Inhibition Dendritic Spine Morphogenesis Regulation Of Biological Quality Cellular Response To Electrical Stimulus Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering
Pathways		ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2
Drugs			Phosphatidylethanolamine
Diseases			Vulvar cancer Breast cancer Malignant melanoma Prostate cancer Hepatocellular carcinoma Small cell lung cancer Endometrial Cancer Glioma
GWAS		Appendicular lean mass ( 33097823) Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 24292274 28165464) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Joint mobility (Beighton score) ( 27182965) Keloid ( 20711176) Refractive error ( 32231278)	Alanine aminotransferase levels ( 33547301) Ambidextrousness ( 32989287) Birth weight ( 31043758) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fasting insulin ( 34059833) Height ( 31562340) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mercury levels ( 26025379) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 32888494) Plateletcrit ( 32888494) Psoriasis ( 28537254) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483) Thyroid stimulating hormone levels ( 32769997 30367059) Type 2 diabetes ( 32499647 24509480) Type 2 diabetes (adjusted for BMI) ( 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		282 interacting genes: ABCB1 ABL1 ABL2 ADRB2 AK6 AKT1 AKT3 AMOT AMOTL1 AMPD2 ANK3 ANKRD13D ANXA13 AP1G2 ARID1A ASPSCR1 AURKC BAIAP2 BAIAP2L1 BIRC6 BMPR1A C15orf62 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDIP1 CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CRTC2 CUEDC1 DAZAP2 DCUN1D1 DDN DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EGR1 ENTREP1 EP300 EPHA5 EPRS1 EPS15 ERBB3 ERBB4 ERMN ERRFI1 ESS2 FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FOXJ3 FYN GABARAP GABARAPL1 GABARAPL2 GBA1 GFUS GJA1 GRB10 GRIN2A GRK4 GRK7 H3-3A HGS HMCES HMGCL HNRNPK HNRNPL HNRNPU HNRNPUL1 HRAS IFITM3 IGF1R IL1B IRS1 IRS2 JHY JUN KCNAB1 KCNAB2 KCNJ16 KIFC3 KLF5 KRAS LATS1 LDLRAD3 LDLRAD4 LINC01198 LITAF LUC7L2 MAML2 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MS4A10 MTMR4 MYCN MYCT1 MYO15B N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NRAS NSRP1 NUDT21 NUMB PARP16 PAX7 PDGFRB PIP4P2 PIP5K1A PIP5K1C PKN2 PLK1 PLK2 PMEPA1 POLR1C POLR2A POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRR7 PRRG2 PRRG4 PSMD4 PTEN PYM1 RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RBM14 RET RFT1 RHBDD1 RHBDD2 RNF11 RNF38 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SAV1 SCAMP3 SCN10A SCN1A SCN5A SCNN1A SCNN1B SCNN1G SEPTIN9 SFTPC SGK1 SGK2 SH3KBP1 SHISA6 SHTN1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SQSTM1 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 STRIP2 SULF1 SYK SYNPO2 SYT1 TAF1B TBC1D7 TCEANC TCP11L1 TEAD2 TGFB1I1 THOC1 THRAP3 TMEM139 TMEM252 TMEM51 TNIK TOM1 TOM1L2 TP53BP2 TP63 TP73 TRERF1 TRIM44 TRIM52 TRPV6 TTYH2 TTYH3 TULP4 TUSC2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2L6 UBE2M UBOX5 URI1 UVRAG VDAC2 VDAC3 WBP1 WBP2 WEE1 YES1 YOD1 ZC3H14	385 interacting genes: AATK ABCF2 ACTL6A ADAR AFP AKAP12 AKT1 AKT3 ALYREF AMOT ANAPC10 ANAPC7 ANG ANP32B ANP32E ANXA2 AR ARF4 ARL3 ARMCX3 ASCC3 ATM ATP5F1A ATP5F1C BCAR1 BEX1 BGLT3 BUB3 CACTIN-AS1 CAD CALM1 CAMK2G CAV1 CBL CCDC180 CCDC47 CCND2 CCT2 CCT3 CCT4 CCT6A CCT8 CDC27 CEP170 CEP97 CFL1 CHD4 CHGB CMAS COL18A1 COPA COPB1 COPS6 CREB1 CSNK1A1 CSNK2A1 CSNK2A2 CUL4B CXCL1 CXXC1 DAP3 DAXX DBN1 DCAF11 DCAF13 DDB1 DDOST DDX1 DDX21 DDX24 DDX47 DDX50 DHX15 DHX9 DLC1 DLG1 DNAJA1 DNAJA2 DNAJA3 DNAJB6 DNAJC10 DPM1 DRG1 DSP EEF2 EIF4E EIF6 EML1 EPHA2 EPRS1 ERBB3 ESR1 EXOSC1 EXOSC2 EXOSC4 EXOSC5 EXOSC7 FARSA FARSB FASN FBL FBXW11 FGF7 FLNA FOXK1 FUBP3 GEMIN4 GNAI1 GNAI2 GNB4 GNL3 GPC4 GSTM2 GTF3C2 GTF3C3 GTF3C5 H2AC4 H2AX HADHA HBA1 HNRNPA1 HNRNPA3 HNRNPAB HNRNPUL1 HSD17B1 HSD17B10 HSP90B1 HSPA4 HSPA4L HSPA8 HSPBP1 HSPD1 HSPH1 IL24 ILF2 ILF3 INS IPO5 IPO7 IRS4 ITPRID2 JUP KBTBD4 KDM1A KIF20B KPNB1 LATS1 LGALS1 LIMA1 LINC00839 LINC01198 LINC02023 LIPF LMNB1 LRPPRC LTV1 MAGED2 MAGI2 MAGI3 MAP2K3 MAST1 MAST2 MAST3 MATR3 MCM2 MCM3 MCM5 MCRS1 MDC1 MDN1 METTL26 MEX3C MKI67 MME MPRIP MRPS22 MRPS23 MRPS27 MRPS28 MRPS7 MRPS9 MSH6 MTHFD2 MVP MYBBP1A MYC MYH10 MYL12A MYO1B MYO1C MYO1D MYOF NACA NCBP1 NCF1 NCSTN NDFIP1 NEDD4 NGB NHERF1 NHERF2 NOP56 NOP58 NPM3 NR3C1 NUMB OSGIN1 PBK PBRM1 PCNA PDGFRB PELO PELP1 PHB1 PHB2 PICK1 PIK3R1 PKM PLEC PLK1 POLDIP2 POLR1A POLR2A POLR2B POLR2H POP1 PPL PPP1CA PPP2CA PRDX1 PRDX3 PRKDC PRPF19 PRPF8 PSMD3 PSMD4 PSMD7 PTDSS1 PTK7 PURA PXN QPCTL RAD21 RANBP2 RANGAP1 RBBP5 RBM15B RBM4 RCC2 RCN1 RFC3 RFC4 RFC5 RING1 RNF31 RPL10 RPL10A RPL12 RPL13 RPL13A RPL14 RPL17 RPL18A RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL27 RPL27A RPL28 RPL30 RPL31 RPL32 RPL34 RPL36 RPL38 RPL7 RPLP0 RPLP2 RPN2 RPP30 RPP38 RPP40 RPS11 RPS13 RPS15 RPS15A RPS17 RPS2 RPS20 RPS23 RPS25 RPS26 RPS27 RPS27A RPS3 RPS4X RPS5 RPS6 RPS9 RSL1D1 RYBP S100A8 S100A9 SDC1 SDC4 SDCBP SEC61A1 SET SETX SHARPIN SHROOM3 SIN3A SIRT4 SKP1 SLC25A1 SLC25A13 SLC25A3 SLC25A5 SMARCA4 SMARCA5 SMC2 SMC4 SMCHD1 SMURF1 SNAI1 SNRNP200 SNRPA1 SNRPB2 SNRPD1 SNTB2 SNX27 SPOP SPTAN1 SPTBN1 SRP14 SSB SSR4 SSRP1 STAG2 STK11 STRAP SUDS3 SUGP2 TCF25 TCP1 TECR TERF2IP THOC2 THOC3 THOC6 TMEFF1 TNKS TNKS2 TNPO3 TP53 TP53BP1 TRIM25 TRIM28 TRMO TUBA1B TUBB TUBB4B TUFM TWIST1 TXN U2AF1 UBE2I UBE2L3 UPF1 USP7 USP9X UTP14A UTRN WWP1 WWP2 XRCC5 XRCC6 YAF2 YAP1 YES1 YTHDC2 YTHDF2 ZNF326
Entrez ID		4734	5728
HPRD ID		03786	03431
Ensembl ID		ENSG00000069869	ENSG00000171862
Uniprot IDs		P46934	F6KD01 P60484
PDB IDs		2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H 5AHT 5C7J 5C91	1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ 7JTX 7JUK 7JUL 7JVX 7PC7 8X3S
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Phosphorylation Intracellular Signal Transduction ATP Binding Nucleotide Binding Phosphorylation WW Domain Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Transferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Serine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Protein Autophosphorylation Signal Transduction Cytoplasm Regulation Of Protein Modification Process Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process MAPK Cascade Positive Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Macromolecule Metabolic Process Positive Regulation Of Cell Communication Apoptotic Process Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Positive Regulation Of Signaling Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Programmed Cell Death Cell Surface Receptor Signaling Pathway Cell Death Regulation Of Apoptotic Process Nucleoplasm Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Projection Organization Response To Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Communication	RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Macromolecule Metabolic Process Translation Nucleolus Nucleoplasm Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cytosol Nucleus Cytosolic Large Ribosomal Subunit Cytoplasm RNA Metabolic Process Extracellular Exosome Focal Adhesion RRNA Metabolic Process Protein Metabolic Process Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Biogenesis RNA Processing Regulation Of DNA Metabolic Process Protein Binding Small Ribosomal Subunit ATP Binding Chromosome, Telomeric Region ATP Hydrolysis Activity Small-subunit Processome Positive Regulation Of DNA Biosynthetic Process RRNA Processing Positive Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ribosomal Small Subunit Biogenesis MRNA Metabolic Process Nucleotide Binding DNA Metabolic Process Protein Localization To Organelle Nucleocytoplasmic Transport Nuclear Transport Regulation Of Telomere Maintenance Positive Regulation Of Protein Localization To Nucleus ATP-dependent Protein Folding Chaperone Positive Regulation Of Chromosome Organization Positive Regulation Of Telomere Maintenance Via Telomerase Chromosome Cadherin Binding
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