MT-ND5 and GLUL

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		MT-ND5	GLUL
Description		NADH dehydrogenase subunit 5	glutamate-ammonia ligase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Cell Body Extracellular Exosome Glial Cell Projection
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity	Nucleotide Binding Catalytic Activity Glutamine Synthetase Activity Protein Binding ATP Binding Transferase Activity Ligase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Electron Transport Coupled Proton Transport Mitochondrial Respiratory Chain Complex I Assembly Response To Hydrogen Peroxide ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis	Angiogenesis L-glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Response To Starvation Response To Glucose Regulation Of Endothelial Cell Migration Protein Palmitoylation Ribosome Biogenesis Positive Regulation Of Erythrocyte Differentiation Intracellular Ammonium Homeostasis Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus
Pathways		Mitochondrial translation termination Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism
Drugs		NADH	L-Glutamine Glutamic acid
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)	Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency
GWAS			Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823) Peak height velocity ( 34047840)
Interacting Genes		2 interacting genes: GLUL LIG4	27 interacting genes: BTG3 CASP8AP2 CRBN CYP39A1 DSCAM DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A LCOR MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 RSPH1 SKIL TAT UBE2I USP15
Entrez ID		4540	2752
HPRD ID		02467	00701
Ensembl ID		ENSG00000198786	ENSG00000135821
Uniprot IDs		P03915 U5ZC31	A8YXX4 P15104
PDB IDs		5XTC 5XTD 5XTH 5XTI	2OJW 2QC8 7EVT 8DNU
Enriched GO Terms of Interacting Partners?		Glutamine Synthetase Activity Intracellular Ammonium Homeostasis Ligase Activity Glutamine Biosynthetic Process Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Ammonium Homeostasis Nucleotide-excision Repair, DNA Gap Filling L-glutamate Catabolic Process DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Regulation Of Protein Localization To Nucleolus Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Lymphoid Progenitor Cell Differentiation AMP Binding Cell Population Proliferation Cellular Response To Lithium Ion Dicarboxylic Acid Catabolic Process Protein Palmitoylation Glutamine Metabolic Process Response To Lithium Ion Regulation Of Cell Development Protein-cysteine S-palmitoyltransferase Activity V(D)J Recombination Positive Regulation Of Cell Differentiation Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Glial Cell Projection Protein Lipidation Somatic Diversification Of Immunoglobulins Involved In Immune Response Response To X-ray Glutamate Metabolic Process Positive Regulation Of Erythrocyte Differentiation Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Somatic Cell DNA Recombination T Cell Differentiation In Thymus Somatic Diversification Of Immunoglobulins Fibroblast Proliferation ATP Binding Regulation Of Sprouting Angiogenesis	PML Body SUMO Transferase Activity SUMO Ligase Activity Transcription Coregulator Activity Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of RNA Metabolic Process Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Purine Ribonucleoside Diphosphate Catabolic Process Transcription Coactivator Binding Nucleoside Diphosphate Catabolic Process Protein Modification Process Apoptotic Signaling Pathway Positive Regulation Of Protein Sumoylation Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ribonucleoside Diphosphate Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Nucleoside Diphosphate Metabolic Process Transcription Corepressor Activity Positive Regulation Of Cell Differentiation Apoptotic Process Purine Nucleotide Catabolic Process Negative Regulation Of Biosynthetic Process Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death Cell Death Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Bile Acid Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Sumoylation Nucleotide Catabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Developmental Process Retina Layer Formation Extrinsic Apoptotic Signaling Pathway Organic Acid Metabolic Process Purine Ribonucleotide Metabolic Process Nucleobase-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy
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