GLUL and CYP39A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GLUL	CYP39A1
Description		glutamate-ammonia ligase	cytochrome P450 family 39 subfamily A member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Cell Body Extracellular Exosome Glial Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Catalytic Activity Glutamine Synthetase Activity Protein Binding ATP Binding Transferase Activity Ligase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Metal Ion Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid 7-alpha-hydroxylase Activity Steroid Hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Metal Ion Binding
	Biological Process	Angiogenesis L-glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Response To Starvation Response To Glucose Regulation Of Endothelial Cell Migration Protein Palmitoylation Ribosome Biogenesis Positive Regulation Of Erythrocyte Differentiation Intracellular Ammonium Homeostasis Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus	Lipid Metabolic Process Bile Acid Biosynthetic Process Cholesterol Catabolic Process Digestion Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Cholesterol Homeostasis
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism	Synthesis of bile acids and bile salts via 24-hydroxycholesterol Endogenous sterols
Drugs		L-Glutamine Glutamic acid
Diseases		Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency
GWAS		Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823) Peak height velocity ( 34047840)	Normal facial asymmetry (deformation magnitude) ( 30631343)
Interacting Genes		27 interacting genes: BTG3 CASP8AP2 CRBN CYP39A1 DSCAM DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A LCOR MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 RSPH1 SKIL TAT UBE2I USP15	4 interacting genes: GLUL ORM2 SERINC1 SMYD3
Entrez ID		2752	51302
HPRD ID		00701	07067
Ensembl ID		ENSG00000135821	ENSG00000146233
Uniprot IDs		A8YXX4 P15104	A0A087WTD2 B7Z786 Q9NYL5
PDB IDs		2OJW 2QC8 7EVT 8DNU
Enriched GO Terms of Interacting Partners?		PML Body SUMO Transferase Activity SUMO Ligase Activity Transcription Coregulator Activity Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of RNA Metabolic Process Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Purine Ribonucleoside Diphosphate Catabolic Process Transcription Coactivator Binding Nucleoside Diphosphate Catabolic Process Protein Modification Process Apoptotic Signaling Pathway Positive Regulation Of Protein Sumoylation Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ribonucleoside Diphosphate Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Nucleoside Diphosphate Metabolic Process Transcription Corepressor Activity Positive Regulation Of Cell Differentiation Apoptotic Process Purine Nucleotide Catabolic Process Negative Regulation Of Biosynthetic Process Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death Cell Death Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Bile Acid Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Sumoylation Nucleotide Catabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Developmental Process Retina Layer Formation Extrinsic Apoptotic Signaling Pathway Organic Acid Metabolic Process Purine Ribonucleotide Metabolic Process Nucleobase-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy	Glutamine Synthetase Activity Intracellular Ammonium Homeostasis Glutamine Biosynthetic Process Ammonium Homeostasis L-glutamate Catabolic Process Membrane Biogenesis RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Regulation Of Protein Localization To Nucleolus Acetyltransferase Activator Activity
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