AFDN and EPHB6

Number of citations of the paper that reports this interaction (PubMedID 9707552)
36

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		AFDN	EPHB6
Description		afadin, adherens junction formation factor	EPH receptor B6
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite
	Molecular Function	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Ephrin Receptor Signaling Pathway
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one	Fostamatinib
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Cancer ( 29299148)
Interacting Genes		41 interacting genes: BCR CCR6 CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RPS6KA2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	28 interacting genes: AFDN ASB12 CBL CRK CRKL DDIT4L DUSP18 DUSP19 EFNB2 EPHB1 ERBB2 GRB2 HDHD2 INCA1 MSX2 MTARC1 NIF3L1 NOTCH2NLA POU6F2 PRMT5 REL SAT1 STYX TCF4 TEKT5 TRIB3 TRIM39 VPS26C
Entrez ID		4301	2051
HPRD ID		01164	04133
Ensembl ID		ENSG00000130396	ENSG00000106123
Uniprot IDs		A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196	A0A0G2JNH7 F8WCM8 O15197
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR	7K7J
Enriched GO Terms of Interacting Partners?		Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules	Ephrin Receptor Binding Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Helper T Cell Diapedesis Cerebellar Neuron Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Inhibitor Activity Cellular Response To Growth Factor Stimulus Ephrin Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Response To Growth Factor Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Neuromuscular Junction Cerebral Cortex Development Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Schwann Cell Development Protein Tyrosine/serine/threonine Phosphatase Activity Establishment Of Cell Polarity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization SH3 Domain Binding Neuron Projection Development Regulation Of Protein Serine/threonine Kinase Activity Cytoplasm Signal Transduction Protein Binding Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Regulation Of Rac Protein Signal Transduction T Cell Migration Identical Protein Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Spermidine Binding
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