AFDN and RPS6KA2

		AFDN	RPS6KA2
Description		afadin, adherens junction formation factor	ribosomal protein S6 kinase A2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Synapse Meiotic Spindle
	Molecular Function	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Oocyte Maturation Brain Renin-angiotensin System Signal Transduction Chemical Synaptic Transmission Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Meiotic Nuclear Division Heart Contraction Regulation Of Protein Processing Cellular Response To Carbohydrate Stimulus
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756 34002096) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) Café-au-lait macule number in neurofibromatosis type1 ( 32869517) Dental caries ( 23259602) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 23128233 27569725) Macrovascular complications in type 2 diabetes ( 33430853) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)
Interacting Genes		41 interacting genes: BCR CCR6 CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RPS6KA2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	19 interacting genes: AFDN BAD CREB1 DYNLT1 DYNLT2 FLNC FOS JUN KCNJ6 L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 OTUD4 SHANK1 TBXT THBS2 TP53
Entrez ID		4301	6196
HPRD ID		01164	03403
Ensembl ID		ENSG00000130396	ENSG00000071242
Uniprot IDs		A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196	B7Z3B5 F2Z2J1 Q15349 X5D337
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR
Enriched GO Terms of Interacting Partners?		Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules	Regulation Of Golgi Inheritance Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Face Development Schwann Cell Development Animal Organ Formation ERBB2 Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Lung Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Regulation Of Stress-activated MAPK Cascade Cell Differentiation Gland Development Anatomical Structure Morphogenesis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cellular Component Organization Response To Lipid Cell Surface Receptor Signaling Pathway Response To Nicotine Transcription Factor AP-1 Complex Regulation Of Cell Development Thymus Development Intracellular Signaling Cassette Cardiac Neural Crest Cell Development Involved In Heart Development Response To Epidermal Growth Factor ERK1 And ERK2 Cascade Positive Regulation Of MiRNA Transcription Outer Ear Morphogenesis Identical Protein Binding Cellular Response To Starvation Positive Regulation Of MiRNA Metabolic Process Glial Cell Development Response To Mechanical Stimulus
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