ATXN3 and WWP2

Number of citations of the paper that reports this interaction (PubMedID 35331737)
83

Data Source:
BioGRID (enzymatic study)

		ATXN3	WWP2
Description		ataxin 3	WW domain containing E3 ubiquitin protein ligase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding ATPase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Transferase Activity Potassium Channel Inhibitor Activity Transmembrane Transporter Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity Transcription Regulator Inhibitor Activity
	Biological Process	Microtubule Cytoskeleton Organization Cytoplasmic Translation Nucleotide-excision Repair Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Cellular Response To Starvation Regulation Of Cell-substrate Adhesion Protein Deubiquitination Actin Cytoskeleton Organization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transport Protein Modification Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways		Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Regulation of PTEN stability and activity RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 31562340 28552196) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Myocardial infarction ( 33532862) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 33082346) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)
Interacting Genes		55 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GABARAP GSK3B KAT2B KPNA2 MAP1LC3A MAP1LC3C MAP3K1 MKNK1 NCOR1 NEDD8 PHAF1 PICK1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2D3 UBE2L3 UBE2S UBE2W UBE4B UBQLN1 USP21 VCP WWP2	118 interacting genes: ANKRD44 ARRDC3 ATN1 ATOSB ATXN3 C3orf70 CALCOCO2 CDC34 CFAP36 CFTR CLCN5 CPSF6 DAG1 DIDO1 DVL2 EFCAB3 EGR2 ENTREP1 EWSR1 FAF1 FAM131B FAM131C FBXL18 FUT3 GADD45GIP1 GAS2L2 GGN GRAP2 HGS HNRNPUL1 IFIT2 IL2RG IL6R IST1 KHDRBS3 LGALS9B MED25 MED4 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 NHERF2 NOTCH4 NUTF2 OPTN PAIP1 PATZ1 PDCD6IP PDLIM7 PLA2G15 PRKAA2 PSMD4 PSMF1 PTEN RABEP2 RAD23A RAD23B RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFMBT1 SFTPC SMAD3 SMAD7 SMR3A SNRPB SNRPC SOX2 SPART SQSTM1 STAM TFAP2A THBS1 TICAM1 TNK2 TOM1 TOM1L2 TP53BP2 TRAF4 TRIP10 UBAC1 UBAP1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBL7 UBQLN1 UBQLN4 UBTD1 USP5 USP7 VASP VPS37C WASF2 WBP1 WBP2 WDR5 WIPF1 ZNF688
Entrez ID		4287	11060
HPRD ID		06131	03812
Ensembl ID		ENSG00000066427	ENSG00000198373
Uniprot IDs		A0A0A0MS38 C9JQV6 P54252	B4DHF6 O00308
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9	4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS 8EI5 8EI6 8EI7 8EI8 9EQH
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cytosol Post-translational Protein Modification Cytoplasm Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Autophagy Positive Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding Protein K63-linked Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Response To Stress Ubiquitin Protein Ligase Activity Nucleus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Mitophagy Macroautophagy Regulation Of Programmed Cell Death Protein Autoubiquitination	Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis WW Domain Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Ubiquitin Binding Protein Polyubiquitination Protein Modification By Small Protein Conjugation Endosome Catabolic Process Nucleoplasm Protein Ubiquitination Cytosol Post-translational Protein Modification Protein K48-linked Ubiquitination Multivesicular Body Assembly Multivesicular Body Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Sensory Perception Of Salty Taste Regulation Of Proteasomal Protein Catabolic Process Endosome Organization Macroautophagy Regulation Of Proteolysis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Perinuclear Region Of Cytoplasm Proteasome Binding Autophagy Protein K11-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Aldosterone Sodium Channel Complex Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process
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