MAGEA6 and NOSTRIN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEA6	NOSTRIN
Description		MAGE family member A6	nitric oxide synthase trafficking
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Histone Deacetylase Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy	Endocytosis Signal Transduction Negative Regulation Of DNA-templated Transcription
Pathways			NOSTRIN mediated eNOS trafficking
Drugs
Diseases
GWAS		Serum alkaline phosphatase levels ( 33339817)	Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Mitochondrial DNA levels ( 25240745) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		76 interacting genes: ACOT7 ACTN3 AKAP6 AKAP9 ANKRD26P1 APOA4 ARFIP1 ATOSA ATP6V1G1 ATPAF2 BCL7B BET1 BFSP2 BOLA3 C1orf216 CAMTA2 CBFA2T2 CCDC146 CCDC185 CCDC187 CCDC24 COL4A6 CTF1 DLGAP3 DLGAP4 DNTTIP1 ELMOD3 EXOC5 FRMPD1 GADD45GIP1 GCSH GFOD1 HAUS1 HLA-DRB4 HNRNPM IQUB KIF27 KLHL38 LCORL LIN37 LIN52 LSM2 MCM7 MCRS1 MED21 MID2 MIPOL1 MORN3 MSGN1 NCK2 NOSTRIN PCBD2 PDE4D PRKAA1 RASSF10 RASSF4 RCOR3 REX1BD RPL37A RUSC1 S100A14 S100A9 SH2D4A SMARCD1 SNAP47 SNX4 SON STAMBPL1 STX5 TRIM26 TRIM28 TSPYL6 TULP3 TXNDC9 XRCC4 ZNF76	7 interacting genes: APC GLA KDM1A MAGEA6 NOS3 PRMT6 TULP3
Entrez ID		4105	115677
HPRD ID		02168	06324
Ensembl ID		ENSG00000197172	ENSG00000163072
Uniprot IDs		P43360	Q8IVI9
PDB IDs			2YUN
Enriched GO Terms of Interacting Partners?		Protein Binding SNARE Complex Suppression Of Viral Release By Host	Endocardial Cushion Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Smooth Muscle Hyperplasia Flavin Adenine Dinucleotide Binding Negative Regulation Of Muscle Hyperplasia Bronchus Morphogenesis Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Intraciliary Transport Particle A Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Signal Transduction Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Demethylase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Glycosylceramide Catabolic Process Cadmium Ion Binding MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Localization To Centrosome Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Negative Regulation Of Oxidoreductase Activity Smooth Muscle Adaptation Regulation Of Systemic Arterial Blood Pressure By Endothelin L-arginine Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Arginine Binding Embryonic Neurocranium Morphogenesis Response To Fungicide Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Ovulation From Ovarian Follicle Tetrahydrobiopterin Metabolic Process
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