MAGEA6 and ACOT7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEA6	ACOT7
Description		MAGE family member A6	acyl-CoA thioesterase 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Histone Deacetylase Binding	Fatty-acyl-CoA Binding Protein Binding Hydrolase Activity Thiolester Hydrolase Activity Long-chain Fatty Acyl-CoA Binding Protein Homodimerization Activity Fatty Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy	Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Fatty Acid Catabolic Process Coenzyme A Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Medium-chain Fatty Acid Biosynthetic Process Palmitic Acid Biosynthetic Process
Pathways			Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases
GWAS		Serum alkaline phosphatase levels ( 33339817)	A body shape index ( 34021172) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) HDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 31628463) QT interval ( 19305408) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		76 interacting genes: ACOT7 ACTN3 AKAP6 AKAP9 ANKRD26P1 APOA4 ARFIP1 ATOSA ATP6V1G1 ATPAF2 BCL7B BET1 BFSP2 BOLA3 C1orf216 CAMTA2 CBFA2T2 CCDC146 CCDC185 CCDC187 CCDC24 COL4A6 CTF1 DLGAP3 DLGAP4 DNTTIP1 ELMOD3 EXOC5 FRMPD1 GADD45GIP1 GCSH GFOD1 HAUS1 HLA-DRB4 HNRNPM IQUB KIF27 KLHL38 LCORL LIN37 LIN52 LSM2 MCM7 MCRS1 MED21 MID2 MIPOL1 MORN3 MSGN1 NCK2 NOSTRIN PCBD2 PDE4D PRKAA1 RASSF10 RASSF4 RCOR3 REX1BD RPL37A RUSC1 S100A14 S100A9 SH2D4A SMARCD1 SNAP47 SNX4 SON STAMBPL1 STX5 TRIM26 TRIM28 TSPYL6 TULP3 TXNDC9 XRCC4 ZNF76	26 interacting genes: ACOT12 ATXN1 ATXN1L BAG4 CAMK2B CDC42 CRYAB DAZAP2 DLC1 ENKD1 FXR1 HOXA1 LMNA MAGEA3 MAGEA6 NCOA5 POT1 POU6F1 SPATC1L TERF1 THAP1 TINF2 UBQLN1 UBQLN2 UBXN1 ZNF438
Entrez ID		4105	11332
HPRD ID		02168	12517
Ensembl ID		ENSG00000197172	ENSG00000097021
Uniprot IDs		P43360	O00154
PDB IDs			2QQ2
Enriched GO Terms of Interacting Partners?		Protein Binding SNARE Complex Suppression Of Viral Release By Host	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Shelterin Complex Negative Regulation Of Metabolic Process Nuclear Telomere Cap Complex Identical Protein Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Telomere Capping Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cellular Component Organization Nucleus Regulation Of ERAD Pathway Telomeric DNA Binding Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Telomere Maintenance Via Telomere Lengthening POZ Domain Binding Negative Regulation Of DNA Biosynthetic Process Telomere Assembly Regulation Of Metabolic Process Nuclear Pore Localization Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Polyubiquitin Modification-dependent Protein Binding Muscle Organ Development Regulation Of Telomere Maintenance Via Telomerase Muscle Structure Development Negative Regulation Of DNA-templated Transcription Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of RNA Biosynthetic Process Cellular Component Assembly Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Organelle Organization Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of ERAD Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Stress Fiber Assembly Regulation Of Chromosome Organization Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Telomere Maintenance Via Telomerase
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