NOSTRIN and GLA

		NOSTRIN	GLA
Description		nitric oxide synthase trafficking	galactosidase alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity
	Biological Process	Endocytosis Signal Transduction Negative Regulation Of DNA-templated Transcription	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		NOSTRIN mediated eNOS trafficking	Neutrophil degranulation Glycosphingolipid catabolism
Drugs			Migalastat
Diseases			Fabry disease
GWAS		Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Mitochondrial DNA levels ( 25240745) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		7 interacting genes: APC GLA KDM1A MAGEA6 NOS3 PRMT6 TULP3	15 interacting genes: ANKRD30A CCR2 COL4A5 DUSP6 GPR17 GUCY2F HNRNPH2 MORF4L2 NAP1L3 NOSTRIN OGT PDE6B PLP1 TERT UBC
Entrez ID		115677	2717
HPRD ID		06324	02357
Ensembl ID		ENSG00000163072	ENSG00000102393
Uniprot IDs		Q8IVI9	A0A3B3IUC4 A0A6Q8PHD1 P06280 Q53Y83
PDB IDs		2YUN	1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT 8K7D 8K7E 8K7F 8K7G 8K7H 8K7I 8K7J 8K7K 8K7L 9AVS
Enriched GO Terms of Interacting Partners?		Endocardial Cushion Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Smooth Muscle Hyperplasia Flavin Adenine Dinucleotide Binding Negative Regulation Of Muscle Hyperplasia Bronchus Morphogenesis Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Intraciliary Transport Particle A Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Signal Transduction Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Demethylase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Glycosylceramide Catabolic Process Cadmium Ion Binding MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Localization To Centrosome Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Negative Regulation Of Oxidoreductase Activity Smooth Muscle Adaptation Regulation Of Systemic Arterial Blood Pressure By Endothelin L-arginine Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Arginine Binding Embryonic Neurocranium Morphogenesis Response To Fungicide Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Ovulation From Ovarian Follicle Tetrahydrobiopterin Metabolic Process
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