RHOG and ELMO2

Number of citations of the paper that reports this interaction (PubMedID 12879077)
0

Data Source:
HPRD (in vitro, in vivo)

		RHOG	ELMO2
Description		ras homolog family member G	engulfment and cell motility 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Cell Chemotaxis Activation Of GTPase Activity Regulation Of Postsynapse Assembly Regulation Of Ruffle Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Phagocytosis Apoptotic Process Actin Filament Organization Cell Motility Cell Chemotaxis
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOG GTPase cycle FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Eosinophilic esophagitis ( 34506852) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)
Interacting Genes		24 interacting genes: ARHGDIA ARHGDIG CCR2 CEBPA DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 RSPH1 SMAD1 SMAD4 TGFBR1 UBC VAV1 VAV2 VAV3	3 interacting genes: DOCK1 DOCK4 RHOG
Entrez ID		391	63916
HPRD ID		01537	12103
Ensembl ID		ENSG00000177105	ENSG00000062598
Uniprot IDs		P84095 Q6ICQ8	Q96JJ3
PDB IDs		6UKA 7Y4A 8XM7 8ZJ2	6IDX 6IE1
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette Guanyl-nucleotide Exchange Factor Activity Small GTPase-mediated Signal Transduction Signal Transduction GTPase Activator Activity Regulation Of Small GTPase Mediated Signal Transduction Phagocytosis I-SMAD Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rho GDP-dissociation Inhibitor Activity Cell Motility Fc-gamma Receptor Signaling Pathway Cell Migration Guanyl-nucleotide Exchange Factor Complex SMAD Protein Complex Heteromeric SMAD Protein Complex Fc Receptor Signaling Pathway Cytosol Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Chemotaxis Cellular Response To Xenobiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Locomotion Platelet Activation Cytoplasm Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Chemotaxis Regulation Of Cell Size Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-6-mediated Signaling Pathway Cardiac Conduction System Development MAPK Cascade Endocytosis Integrin-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Extracellular Matrix Assembly SH3 Domain Binding SMAD Protein Signal Transduction Small GTPase Binding Positive Regulation Of Extracellular Matrix Organization Response To Xenobiotic Stimulus	Regulation Of Postsynapse Assembly Regulation Of Postsynapse Organization Regulation Of Synapse Assembly Postsynapse Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Synapse Organization Glutamatergic Synapse Intracellular Signaling Cassette SH3 Domain Binding Cell Migration Cell Motility Cell Chemotaxis Guanyl-nucleotide Exchange Factor Activity Negative Regulation Of Vascular Associated Smooth Muscle Contraction GTPase Activator Activity Small GTPase Binding Intracellular Signal Transduction Chemotaxis Locomotion Guanyl-nucleotide Exchange Factor Complex Stereocilium Bundle Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Vasoconstriction Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Activation Of GTPase Activity Rac Protein Signal Transduction Myoblast Fusion Regulation Of Ruffle Assembly Phagocytosis, Engulfment Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Organelle Syncytium Formation Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Stereocilium Cortical Cytoskeleton Organization Membrane Invagination Positive Regulation Of Epithelial Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Smooth Muscle Contraction
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