ELMO2

Description		engulfment and cell motility 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding
	Biological Process	Phagocytosis Apoptotic Process Actin Filament Organization Cell Motility Cell Chemotaxis
Pathways		Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOG GTPase cycle FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS
Novel Interacting Genes		3 novel interacting genes: DOCK1 DOCK4 RHOG
Interacting Genes		3 interacting genes: DOCK1 DOCK4 RHOG
Entrez ID		63916
HPRD ID		12103
Ensembl ID		ENSG00000062598
Uniprot IDs		Q96JJ3
PDB IDs		6IDX 6IE1
Enriched GO Terms of Interacting Partners?		Regulation Of Postsynapse Assembly Regulation Of Postsynapse Organization Regulation Of Synapse Assembly Postsynapse Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Synapse Organization Glutamatergic Synapse Intracellular Signaling Cassette SH3 Domain Binding Cell Migration Cell Motility Cell Chemotaxis Guanyl-nucleotide Exchange Factor Activity Negative Regulation Of Vascular Associated Smooth Muscle Contraction GTPase Activator Activity Small GTPase Binding Intracellular Signal Transduction Chemotaxis Locomotion Guanyl-nucleotide Exchange Factor Complex Stereocilium Bundle Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Vasoconstriction Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Activation Of GTPase Activity Rac Protein Signal Transduction Myoblast Fusion Regulation Of Ruffle Assembly Phagocytosis, Engulfment Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Organelle Syncytium Formation Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Stereocilium Cortical Cytoskeleton Organization Membrane Invagination Positive Regulation Of Epithelial Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Smooth Muscle Contraction
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