RHOG and IQGAP2

Number of citations of the paper that reports this interaction (PubMedID 12376551)
0

Data Source:
HPRD (in vitro)

		RHOG	IQGAP2
Description		ras homolog family member G	IQ motif containing GTPase activating protein 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Microtubule Plasma Membrane Microvillus Cell Cortex Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Cell Leading Edge Extracellular Exosome Plasma Membrane Bounded Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Actin Binding GTPase Inhibitor Activity GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Small GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Cell Chemotaxis Activation Of GTPase Activity Regulation Of Postsynapse Assembly Regulation Of Ruffle Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Signal Transduction Regulation Of Actin Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Thrombin-activated Receptor Signaling Pathway Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	RHO GTPases activate IQGAPs Neutrophil degranulation CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Eosinophilic esophagitis ( 34506852) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)	A body shape index ( 34021172) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Late-onset Alzheimer's disease ( 27770636) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 32888494 27863252) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		24 interacting genes: ARHGDIA ARHGDIG CCR2 CEBPA DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 RSPH1 SMAD1 SMAD4 TGFBR1 UBC VAV1 VAV2 VAV3	6 interacting genes: ACTR2 ALG8 CALM1 CDC42 RAC1 RHOG
Entrez ID		391	10788
HPRD ID		01537	09253
Ensembl ID		ENSG00000177105	ENSG00000145703
Uniprot IDs		P84095 Q6ICQ8	B7Z7U6 B7Z7X2 F5H7S7 Q13576 Q59HA3
PDB IDs		6UKA 7Y4A 8XM7 8ZJ2	3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette Guanyl-nucleotide Exchange Factor Activity Small GTPase-mediated Signal Transduction Signal Transduction GTPase Activator Activity Regulation Of Small GTPase Mediated Signal Transduction Phagocytosis I-SMAD Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rho GDP-dissociation Inhibitor Activity Cell Motility Fc-gamma Receptor Signaling Pathway Cell Migration Guanyl-nucleotide Exchange Factor Complex SMAD Protein Complex Heteromeric SMAD Protein Complex Fc Receptor Signaling Pathway Cytosol Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Chemotaxis Cellular Response To Xenobiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Locomotion Platelet Activation Cytoplasm Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Chemotaxis Regulation Of Cell Size Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-6-mediated Signaling Pathway Cardiac Conduction System Development MAPK Cascade Endocytosis Integrin-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Extracellular Matrix Assembly SH3 Domain Binding SMAD Protein Signal Transduction Small GTPase Binding Positive Regulation Of Extracellular Matrix Organization Response To Xenobiotic Stimulus	Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Organization Actin Filament Organization Cellular Response To Type II Interferon G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Response To Type II Interferon Actin Filament-based Process Thioesterase Binding Focal Adhesion Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Postsynapse Organization Cell Projection GTP-dependent Protein Binding Cytoskeleton Regulation Of Plasma Membrane Bounded Cell Projection Organization Rac Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Ruffle Assembly Phagocytosis, Engulfment Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Postsynapse Assembly Substantia Nigra Development Cortical Cytoskeleton Organization Regulation Of Synapse Organization Membrane Invagination GTPase Activity Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Endoplasmic Reticulum Membrane GTP Binding Cell Projection Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development Regulation Of Actin Filament-based Process
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