CEP85L and PCNT

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CEP85L	PCNT
Description		centrosomal protein 85L	pericentrin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Cytoskeleton	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite
	Molecular Function	Protein Binding	Protein Binding Calmodulin Binding Molecular Adaptor Activity
	Biological Process	Neuron Migration	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases			Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Atrial fibrillation ( 29892015) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Electrocardiographic traits (multivariate) ( 32602732) QRS duration ( 27659466) Rapid automised naming of digits ( 30741946) RR interval (heart rate) ( 30679814)	Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)
Interacting Genes		5 interacting genes: ITSN1 PCNT PSMD9 TEX11 ZNF417	65 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CDK12 CEP55 CEP85L COL6A1 CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HPRT1 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NDUFV3 NECAB1 NIPBL ODF2L PARVB PCM1 PDE9A PFKL PKNOX1 PNISR RAC3 RPRD1A RRBP1 RTRAF S100B SEPTIN7 SH3BGR SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1
Entrez ID		387119	5116
HPRD ID		12874	05804
Ensembl ID		ENSG00000111860	ENSG00000160299
Uniprot IDs		Q3ZCQ5 Q5SZL2	O95613
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Molecular Adaptor Activity Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Proteasome Regulatory Particle Assembly Positive Regulation Of Hormone Secretion Positive Regulation Of Caveolin-mediated Endocytosis Clathrin-dependent Synaptic Vesicle Endocytosis Gene Conversion Male Meiosis Chromosome Segregation Meiotic Gene Conversion Positive Regulation Of Protein Transport Regulation Of Caveolin-mediated Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Chiasma Assembly Regulation Of Hormone Secretion Central Element Postsynaptic Endocytic Zone Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Secretion By Cell Postsynaptic Actin Cytoskeleton Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Secretion Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Regulation Of Growth Hormone Secretion Proteasome Assembly Meiotic Chromosome Segregation Regulation Of Modification Of Postsynaptic Structure Apical Dendrite Proline-rich Region Binding Resolution Of Meiotic Recombination Intermediates Ectopic Germ Cell Programmed Cell Death Regulation Of Protein Transport Positive Regulation Of Protein Localization Intracellular Vesicle Regulation Of Modification Of Synaptic Structure Synaptonemal Complex Assembly Programmed Cell Death Involved In Cell Development Regulation Of Transport Synaptonemal Complex Synaptonemal Complex Organization BHLH Transcription Factor Binding Reciprocal Meiotic Recombination Microtubule Nucleation Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Clathrin-dependent Endocytosis	Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity
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