PCNT and SRGAP2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PCNT	SRGAP2
Description		pericentrin	SLIT-ROBO Rho GTPase activating protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Phagocytic Vesicle Glutamatergic Synapse
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Nervous System Development Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synapse Assembly Dendritic Spine Development Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Neuron Migration
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)	Asthma ( 32296059) Cholesterol and Triglycerides ( 23031429) Refractive error ( 32231278) Type 2 diabetes ( 30297969)
Interacting Genes		65 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CDK12 CEP55 CEP85L COL6A1 CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HPRT1 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NDUFV3 NECAB1 NIPBL ODF2L PARVB PCM1 PDE9A PFKL PKNOX1 PNISR RAC3 RPRD1A RRBP1 RTRAF S100B SEPTIN7 SH3BGR SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	6 interacting genes: DISC1 EXOC1 FASLG PCNT ROBO1 YWHAG
Entrez ID		5116	23380
HPRD ID		05804	18520
Ensembl ID		ENSG00000160299	ENSG00000266028
Uniprot IDs		O95613	A0A075B7B5 A0A1S5UZH8 B4DFE5 B7Z3G4 B7ZM87 O75044
PDB IDs			2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	Positive Regulation Of Signal Transduction Positive Regulation Of Phospholipid Translocation Positive Regulation Of Cell Communication Cytoplasmic Vesicle Lumen Perinuclear Region Of Cytoplasm Positive Regulation Of Signaling Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Microtubule Organizing Center Molecular Adaptor Activity Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Roundabout Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration TOR Signaling Protein Kinase C Inhibitor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Positive Regulation Of Cellular Component Organization Cytoplasm Regulation Of Plasma Membrane Organization Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Intracellular Signal Transduction Signal Transduction Necroptotic Signaling Pathway Inflammatory Cell Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phospholipid Transport Intracellular Chloride Ion Homeostasis Endosomal Lumen Acidification Negative Regulation Of Multicellular Organismal Process Necroptotic Process Regulation Of Developmental Process Microtubule Cell Projection Organization Cilium Assembly Plasma Membrane Bounded Cell Projection Organization Cilium Organization LRR Domain Binding Endocardial Cushion Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Heart Induction Positive Regulation Of Neurogenesis Axon Guidance Receptor Activity Axon Choice Point Recognition Positive Regulation Of Nervous System Development
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