KRT14 and ENKD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT14	ENKD1
Description		keratin 14	enkurin domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery	Spindle Pole Cytoplasm Centrosome Centriole Spindle Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Ciliary Basal Body Cell Projection Ciliary Base 9+0 Non-motile Cilium
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding	Protein Binding Microtubule Binding Alpha-tubulin Binding
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Response To Radiation Keratinocyte Differentiation Hair Cycle Intermediate Filament Organization Intermediate Filament Bundle Assembly Stem Cell Differentiation	Establishment Of Mitotic Spindle Orientation Cell Projection Organization Motile Cilium Assembly Non-motile Cilium Assembly
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dermatopathia pigmentosa reticularis Naegeli-Franceschetti-Jadassohn syndrome
GWAS			Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		35 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DRC4 DST ENKD1 HGS HSPA5 KIFC3 KRT1 KRT3 KRT4 KRT5 KRT6C KRT72 KRT77 KRT78 KRT79 KRT80 KRT81 KRT85 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1	208 interacting genes: ABI1 ABI2 ACOT7 ACTMAP AKAP8L ANKRD23 ANKRD49 APP ARMC5 ASB3 AVPI1 BANP BCAS2 BCAS4 BCAT1 BEGAIN BEX3 BLZF1 BRAT1 C18orf54 C1orf105 CALCOCO1 CALCOCO2 CBY1 CBY2 CCDC102B CCDC13 CCDC136 CCDC28B CCDC85B CDCA4 CDPF1 CDR2 CDSN CEP55 CEP70 CHCHD3 CHRDL2 COA7 CTBP2 CYSRT1 DGCR6 DVL2 DVL3 DYDC1 ECM1 EEIG1 EFHC2 EIF4G1 EYA2 EZHIP FAM228A FAM90A1 FCHSD2 FKBP6 FOS FOSB FSD2 GADD45G GADD45GIP1 GET4 GFAP GIGYF1 GOLGA2 GOLGA6A GOLGA6L9 GPRASP3 GRHL3 GRIPAP1 HMBOX1 HNRNPH1 HOMEZ HOOK2 HOXA1 HSF2BP HSPB2 HSPB2-C11orf52 ID2 IGF1 IGFBP6 IKBKG IKZF3 JAKMIP1 KIFC3 KLHL20 KLHL26 KRT14 KRT15 KRT31 KRT35 KRT40 KRTAP10-5 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP4-11 KRTAP5-9 KRTAP6-2 LDOC1 LHX3 LIN7B LMO2 LRRC61 LZTS1 MAPK9 MATN4 MDFI MEIS3 MESD METTL27 MID2 MIF4GD MIPOL1 MISP MKRN3 MLH1 MORN3 MORN5 MRNIP MRPL28 MRPL38 MTUS2 MYF5 MYOZ3 N4BP3 NAB2 NBPF22P NBPF6 NCKIPSD NDUFB7 NEFL NFKBIA NHLRC4 NUTM1 OOEP PAK5 PDLIM7 PDZD4 PHC2 PIBF1 PICK1 PIK3R3 PKNOX2 PLSCR1 PNMA1 PNMA2 POLR3C PPP1CC PPP2R3C PRDM14 PRDM6 RAD54B RBCK1 RBM11 RBPMS RCN1 RUBCN RUNDC3A SLC15A2 SNRNP48 SORBS3 SPAG5 SPDEF SPSB3 SRGAP3 SSC4D STAC3 STXBP4 TENT5B TFIP11 TNNI1 TNS2 TOX2 TRAF1 TRAF2 TRAK1 TRGV7 TRIM23 TRIM27 TRIM35 TRIM54 TSC1 TSC22D4 TSEN15 UBXN11 USH1C USH1G USHBP1 USP20 VBP1 VPS37B VWC2 WDR62 WWOX YWHAE ZBTB14 ZC2HC1C ZFP90 ZNF143 ZNF426 ZNF511 ZNF581 ZNF76 ZRANB1
Entrez ID		3861	84080
HPRD ID		01017	13151
Ensembl ID		ENSG00000186847	ENSG00000124074
Uniprot IDs		P02533	Q9H0I2
PDB IDs		3TNU 6JFV
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Keratinization Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Anchoring Junction Cytosol Cytoskeleton Extracellular Exosome Desmosome Cell-cell Junction Organization Cell Junction Organization Adherens Junction Polymeric Cytoskeletal Fiber Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cell-cell Junction Assembly Actin-based Cell Projection Intermediate Filament Cytoskeleton Microtubule Binding Microtubule Cytoskeleton Cell Junction Assembly Cornified Envelope Protein Binding SCAR Complex Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Structural Molecule Activity Signaling Adaptor Activity Lamellipodium Microtubule Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Microtubule Plus-end Binding Cell-cell Junction Maintenance Cytoskeletal Anchor Activity Structural Constituent Of Cytoskeleton Regulation Of Cell Projection Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Intermediate Filament Polymerization Interleukin-5 Receptor Complex COP9 Signalosome	Protein Binding Intermediate Filament Identical Protein Binding Keratin Filament Cytoskeleton Cytosol Intermediate Filament Organization Nucleus Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization
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