ENKD1 and SPSB3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ENKD1	SPSB3
Description		enkurin domain containing 1	splA/ryanodine receptor domain and SOCS box containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Centriole Spindle Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Ciliary Basal Body Cell Projection Ciliary Base 9+0 Non-motile Cilium	Nucleus Cytosol SCF Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Microtubule Binding Alpha-tubulin Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Cell Projection Organization Motile Cilium Assembly Non-motile Cilium Assembly	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways			Neddylation
Drugs
Diseases
GWAS		Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Appendicular lean mass ( 33097823) Plateletcrit ( 32888494) PR interval ( 32439900)
Interacting Genes		208 interacting genes: ABI1 ABI2 ACOT7 ACTMAP AKAP8L ANKRD23 ANKRD49 APP ARMC5 ASB3 AVPI1 BANP BCAS2 BCAS4 BCAT1 BEGAIN BEX3 BLZF1 BRAT1 C18orf54 C1orf105 CALCOCO1 CALCOCO2 CBY1 CBY2 CCDC102B CCDC13 CCDC136 CCDC28B CCDC85B CDCA4 CDPF1 CDR2 CDSN CEP55 CEP70 CHCHD3 CHRDL2 COA7 CTBP2 CYSRT1 DGCR6 DVL2 DVL3 DYDC1 ECM1 EEIG1 EFHC2 EIF4G1 EYA2 EZHIP FAM228A FAM90A1 FCHSD2 FKBP6 FOS FOSB FSD2 GADD45G GADD45GIP1 GET4 GFAP GIGYF1 GOLGA2 GOLGA6A GOLGA6L9 GPRASP3 GRHL3 GRIPAP1 HMBOX1 HNRNPH1 HOMEZ HOOK2 HOXA1 HSF2BP HSPB2 HSPB2-C11orf52 ID2 IGF1 IGFBP6 IKBKG IKZF3 JAKMIP1 KIFC3 KLHL20 KLHL26 KRT14 KRT15 KRT31 KRT35 KRT40 KRTAP10-5 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP4-11 KRTAP5-9 KRTAP6-2 LDOC1 LHX3 LIN7B LMO2 LRRC61 LZTS1 MAPK9 MATN4 MDFI MEIS3 MESD METTL27 MID2 MIF4GD MIPOL1 MISP MKRN3 MLH1 MORN3 MORN5 MRNIP MRPL28 MRPL38 MTUS2 MYF5 MYOZ3 N4BP3 NAB2 NBPF22P NBPF6 NCKIPSD NDUFB7 NEFL NFKBIA NHLRC4 NUTM1 OOEP PAK5 PDLIM7 PDZD4 PHC2 PIBF1 PICK1 PIK3R3 PKNOX2 PLSCR1 PNMA1 PNMA2 POLR3C PPP1CC PPP2R3C PRDM14 PRDM6 RAD54B RBCK1 RBM11 RBPMS RCN1 RUBCN RUNDC3A SLC15A2 SNRNP48 SORBS3 SPAG5 SPDEF SPSB3 SRGAP3 SSC4D STAC3 STXBP4 TENT5B TFIP11 TNNI1 TNS2 TOX2 TRAF1 TRAF2 TRAK1 TRGV7 TRIM23 TRIM27 TRIM35 TRIM54 TSC1 TSC22D4 TSEN15 UBXN11 USH1C USH1G USHBP1 USP20 VBP1 VPS37B VWC2 WDR62 WWOX YWHAE ZBTB14 ZC2HC1C ZFP90 ZNF143 ZNF426 ZNF511 ZNF581 ZNF76 ZRANB1	6 interacting genes: CFTR CSNK2B ENKD1 MAPK8IP2 NUMBL ZNF396
Entrez ID		84080	90864
HPRD ID		13151	18107
Ensembl ID		ENSG00000124074	ENSG00000162032
Uniprot IDs		Q9H0I2	Q6PJ21
PDB IDs			8OKX 8OL1
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament Identical Protein Binding Keratin Filament Cytoskeleton Cytosol Intermediate Filament Organization Nucleus Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization	Positive Regulation Of Anion Channel Activity Anatomical Structure Morphogenesis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Neuroblast Division In Subventricular Zone Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Release From Viral Latency Adiponectin-activated Signaling Pathway Signal Complex Assembly Nonassociative Learning Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Neuron Projection Morphogenesis Cell Projection Morphogenesis JUN Kinase Binding 9+0 Non-motile Cilium Regulation Of Monoatomic Anion Transport Cytoplasm Epithelial Fluid Transport Endothelial Tube Morphogenesis Cell Projection Organization Lateral Ventricle Development MAP-kinase Scaffold Activity Golgi-associated Vesicle Membrane
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