KRT14 and TRADD

Number of citations of the paper that reports this interaction (PubMedID 11684708)
41

Data Source:
HPRD (in vitro)

		KRT14	TRADD
Description		keratin 14	TNFRSF1A associated via death domain
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery	Tumor Necrosis Factor Receptor Superfamily Complex Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex Receptor Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Molecular Adaptor Activity Death Domain Binding
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Response To Radiation Keratinocyte Differentiation Hair Cycle Intermediate Filament Organization Intermediate Filament Bundle Assembly Stem Cell Differentiation	Apoptotic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Inflammatory Response Positive Regulation Of Hair Follicle Development Cellular Response To Tumor Necrosis Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Myoepithelial Cells	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Dimerization of procaspase-8 TNF signaling Defective RIPK1-mediated regulated necrosis
Drugs		Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dermatopathia pigmentosa reticularis Naegeli-Franceschetti-Jadassohn syndrome
GWAS
Interacting Genes		35 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DRC4 DST ENKD1 HGS HSPA5 KIFC3 KRT1 KRT3 KRT4 KRT5 KRT6C KRT72 KRT77 KRT78 KRT79 KRT80 KRT81 KRT85 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1	24 interacting genes: APBB2 BCL10 BIRC2 CNTRL DAPK1 FADD FAS HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TMC8 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP
Entrez ID		3861	8717
HPRD ID		01017	04610
Ensembl ID		ENSG00000186847	ENSG00000102871
Uniprot IDs		P02533	Q15628
PDB IDs		3TNU 6JFV	1F2H 1F3V 5XME 6AC0 7CSQ
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Keratinization Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Anchoring Junction Cytosol Cytoskeleton Extracellular Exosome Desmosome Cell-cell Junction Organization Cell Junction Organization Adherens Junction Polymeric Cytoskeletal Fiber Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cell-cell Junction Assembly Actin-based Cell Projection Intermediate Filament Cytoskeleton Microtubule Binding Microtubule Cytoskeleton Cell Junction Assembly Cornified Envelope Protein Binding SCAR Complex Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Structural Molecule Activity Signaling Adaptor Activity Lamellipodium Microtubule Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Microtubule Plus-end Binding Cell-cell Junction Maintenance Cytoskeletal Anchor Activity Structural Constituent Of Cytoskeleton Regulation Of Cell Projection Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Intermediate Filament Polymerization Interleukin-5 Receptor Complex COP9 Signalosome	Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Death Receptor Activity Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Death-inducing Signaling Complex Tumor Necrosis Factor Binding Negative Regulation Of Apoptotic Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Lymphocyte Apoptotic Process Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Activity Thioesterase Binding CD40 Receptor Complex Neuron Apoptotic Process Leukocyte Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Signaling Receptor Activity Negative Regulation Of Necroptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Negative Regulation Of Programmed Necrotic Cell Death
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