KRT1 and PI3

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
BioGRID (pull down)

		KRT1	PI3
Description		keratin 1	peptidase inhibitor 3
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis Peptidase Inhibitor Activity
	Biological Process	Complement Activation, Lectin Pathway Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Intermediate Filament Organization Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier	Copulation Peptide Cross-linking Antibacterial Humoral Response Innate Immune Response
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Antimicrobial peptides Formation of the cornified envelope
Drugs		Zinc Copper Zinc acetate
Diseases		Ichthyosis hystrix, Curth-Macklin type Epidermolytic palmoplantar keratoderma (EPPK) Striate palmoplantar keratoderma Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
GWAS			Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Malaria ( 31844061)
Interacting Genes		56 interacting genes: - AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT5 KRT6A LINC00839 LORICRIN MBL2 NINL NUP62 OGT PDE4DIP PI3 PRKCE RINT1 RNF26 SGTB TFIP11 TLCD4 TRIM54 U2AF1 UBE3A YWHAQ	6 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN SRC
Entrez ID		3848	5266
HPRD ID		00763	15947
Ensembl ID		ENSG00000167768	ENSG00000124102
Uniprot IDs		P04264	P19957
PDB IDs		4ZRY 6E2J 6UUI	1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Epithelial Cell Differentiation Cytoskeleton Organization Supramolecular Fiber Organization Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organelle Organization Cornified Envelope Peptide Cross-linking Structural Constituent Of Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Keratinocyte Differentiation Extracellular Exosome Cellular Developmental Process Epidermis Development Cytosol Epidermal Cell Differentiation Keratinization Hair Cycle Developmental Process Centrosome Cycle Intermediate Filament Cytoskeleton Hair Follicle Morphogenesis Microtubule Organizing Center Organization Protein Localization To Perinuclear Region Of Cytoplasm Tissue Development Cell Surface Pattern Recognition Receptor Signaling Pathway Fanconi Anaemia Nuclear Complex	Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Protein Metabolic Process Protein Modification Process Cytoskeleton Organization Structural Constituent Of Skin Epidermis Epithelial Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Macromolecule Metabolic Process Developmental Process Elastin Catabolic Process Pancreas Morphogenesis Epidermis Development Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Intermediate Filament Peptidase Inhibitor Complex Cellular Response To Progesterone Stimulus Elastin Metabolic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Antibacterial Peptide Production Regulation Of Defense Response Negative Regulation Of Inflammatory Response Negative Regulation Of Neutrophil Activation Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Dephosphorylation Osteoclast Development Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Signal Complex Assembly Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Signaling Receptor Activator Activity Cell Differentiation Exocrine Pancreas Development Digestive System Development Regulation Of Antimicrobial Humoral Response Regulation Of Immune Response Complement Activation, Lectin Pathway Negative Regulation Of Defense Response Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Lamellipodium Morphogenesis Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Positive Regulation Of Integrin Activation Phospholipase Activator Activity
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