PI3

Description		peptidase inhibitor 3
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis Peptidase Inhibitor Activity
	Biological Process	Copulation Peptide Cross-linking Antibacterial Humoral Response Innate Immune Response
Pathways		Antimicrobial peptides Formation of the cornified envelope
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Malaria ( 31844061)
Novel Interacting Genes		6 novel interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN SRC
Interacting Genes		6 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN SRC
Entrez ID		5266
HPRD ID		15947
Ensembl ID		ENSG00000124102
Uniprot IDs		P19957
PDB IDs		1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Protein Metabolic Process Protein Modification Process Cytoskeleton Organization Structural Constituent Of Skin Epidermis Epithelial Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Macromolecule Metabolic Process Developmental Process Elastin Catabolic Process Pancreas Morphogenesis Epidermis Development Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Intermediate Filament Peptidase Inhibitor Complex Cellular Response To Progesterone Stimulus Elastin Metabolic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Antibacterial Peptide Production Regulation Of Defense Response Negative Regulation Of Inflammatory Response Negative Regulation Of Neutrophil Activation Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Dephosphorylation Osteoclast Development Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Signal Complex Assembly Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Signaling Receptor Activator Activity Cell Differentiation Exocrine Pancreas Development Digestive System Development Regulation Of Antimicrobial Humoral Response Regulation Of Immune Response Complement Activation, Lectin Pathway Negative Regulation Of Defense Response Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Lamellipodium Morphogenesis Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Positive Regulation Of Integrin Activation Phospholipase Activator Activity
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