PI3 and CELA1

Number of citations of the paper that reports this interaction (PubMedID 8794736)
0

Data Source:
HPRD (in vivo)

		PI3	CELA1
Description		peptidase inhibitor 3	chymotrypsin like elastase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Copulation Peptide Cross-linking Antibacterial Humoral Response Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Tissue Remodeling Digestive System Development Elastin Catabolic Process Pancreas Morphogenesis
Pathways		Antimicrobial peptides Formation of the cornified envelope
Drugs			N,N-dimethylformamide Cumidine Mdl 101,146 2-[5-Methanesulfonylamino-2-(4-Aminophenyl)-6-Oxo-1,6-Dihydro-1-Pyrimidinyl]-N-(3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl)Acetamide N-{4-[(Carboxymethyl)carbamoyl]benzoyl}-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-3-pentanyl]-L-prolinamide N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-alanyl-L-alaninamide N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide Freselestat (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATE (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Malaria ( 31844061)	Neutrophil count ( 32888494) Obesity-related traits ( 23251661)
Interacting Genes		6 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN SRC	8 interacting genes: A2M CDK2 CSN2 ERBB3 LPA PI3 SERPINA1 SERPINA3
Entrez ID		5266	1990
HPRD ID		15947	00553
Ensembl ID		ENSG00000124102	ENSG00000139610
Uniprot IDs		P19957	Q9UNI1
PDB IDs		1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Protein Metabolic Process Protein Modification Process Cytoskeleton Organization Structural Constituent Of Skin Epidermis Epithelial Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Macromolecule Metabolic Process Developmental Process Elastin Catabolic Process Pancreas Morphogenesis Epidermis Development Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Intermediate Filament Peptidase Inhibitor Complex Cellular Response To Progesterone Stimulus Elastin Metabolic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Antibacterial Peptide Production Regulation Of Defense Response Negative Regulation Of Inflammatory Response Negative Regulation Of Neutrophil Activation Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Dephosphorylation Osteoclast Development Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Signal Complex Assembly Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Signaling Receptor Activator Activity Cell Differentiation Exocrine Pancreas Development Digestive System Development Regulation Of Antimicrobial Humoral Response Regulation Of Immune Response Complement Activation, Lectin Pathway Negative Regulation Of Defense Response Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Lamellipodium Morphogenesis Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Positive Regulation Of Integrin Activation Phospholipase Activator Activity	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Endopeptidase Inhibitor Activity Extracellular Region Platelet Alpha Granule Lumen Extracellular Space Extracellular Matrix Acute-phase Response Growth Factor Binding Acute Inflammatory Response Plasma Lipoprotein Particle Negative Regulation Of Complement Activation, Lectin Pathway Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Copulation Protease Binding Interleukin-8 Binding Blood Microparticle Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Neuregulin Receptor Activity X Chromosome ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Tumor Necrosis Factor Binding Interleukin-1 Binding Protection From Non-homologous End Joining At Telomere Schwann Cell Differentiation Regulation Of Heterochromatin Formation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway
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