KIR3DL1 and FPR1

		KIR3DL1	FPR1
Description		killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	formyl peptide receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Plasma Membrane Membrane Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding HLA-B Specific Inhibitory MHC Class I Receptor Activity Molecular Adaptor Activity	G Protein-coupled Receptor Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding RAGE Receptor Binding
	Biological Process	Immune Response-regulating Signaling Pathway Immune Response Natural Killer Cell Mediated Cytotoxicity	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Signaling
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Interleukin-10 signaling Neutrophil degranulation
Drugs			Nedocromil
Diseases
GWAS		Lymphocyte count ( 32888494) Ulcerative colitis ( 28067908)	Alopecia areata ( 25608926) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		11 interacting genes: BMP10 CDK3 FPR1 HLA-B KIR2DS1 KIR2DS5 KIR3DS1 RPS6KB1 SMCO4 TAFA2 THSD7B	6 interacting genes: ACTG1 ANXA1 GNAI2 GRK2 KIR3DL1 SAA1
Entrez ID		3811	2357
HPRD ID		09226	00646
Ensembl ID		ENSG00000167633	ENSG00000171051
Uniprot IDs		P43629 Q5UCE2 Q6H2G3 Q8N6C9	P21462
PDB IDs		3VH8 3WUW 5B38 5B39 5T6Z 5T70 6V3J 7K80 7K81 9BL2 9BL3 9BL4 9BL5 9BL6 9BL9 9BLA	7EUO 7T6T 7VFX 7WVU
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Immune Response-regulating Signaling Pathway	G Protein-coupled Receptor Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Regulation Of Secretion By Cell Regulation Of Transport Negative Regulation Of Exocytosis Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Wound Healing Granulocyte Chemotaxis Basal Body Patch Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Actin Filament Granulocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Vesicle-mediated Transport Edg-2 Lysophosphatidic Acid Receptor Binding Regulation Of Interleukin-1 Production Mononuclear Cell Migration HLA-B Specific Inhibitory MHC Class I Receptor Activity Positive Regulation Of Locomotion Myeloid Leukocyte Migration Regulation Of Wound Healing Leukocyte Chemotaxis Negative Regulation Of Secretion By Cell Regulation Of Transepithelial Transport Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Myoblast Migration Involved In Skeletal Muscle Regeneration Positive Regulation Of Neutrophil Apoptotic Process Protein Localization To Bicellular Tight Junction Regulation Of Cell Adhesion Regulation Of Response To Wounding Dense Body Morphogenesis Of A Polarized Epithelium Cytoplasmic Side Of Mitochondrial Outer Membrane G Protein-coupled Receptor Signaling Pathway Regulation Of The Force Of Heart Contraction By Chemical Signal Alpha-2A Adrenergic Receptor Binding Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Apoptotic Process Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Secretion Regulation Of Exocytosis Cell Chemotaxis Neutrophil Clearance
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