JAG2 and CKB

		JAG2	CKB
Description		jagged canonical Notch ligand 2	creatine kinase B
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ubiquitin Protein Ligase Binding
	Biological Process	Skeletal System Development In Utero Embryonic Development Respiratory System Process Cell Communication Notch Signaling Pathway Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Notch Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis	Substantia Nigra Development Phosphocreatine Biosynthetic Process Futile Creatine Cycle
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Creatine metabolism RND3 GTPase cycle
Drugs			Creatine Phosphocreatine
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting plasma glucose ( 31932636) Red blood cell count ( 32888494)	Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Height ( 28552196 31562340) Schizophrenia ( 25056061)
Interacting Genes		13 interacting genes: ATN1 ATXN7 CACNA1A CKB GFI1B HOXA1 KLC1 MBD1 MIB2 NOTCH1 NOTCH2 NOTCH3 SHANK3	29 interacting genes: ACD ARIH2 ASB9 CKM CUL5 DIO3 DNAH5 EML1 ERBB2 EVL FUT8 GOLGA2 GPR65 IFI27 ILK JAG2 MLH1 OGT POT1 PPP1CA PSEN1 SERP2 SMG5 SNCA TAB1 TERF1 TINF2 TRIM63 UBE3A
Entrez ID		3714	1152
HPRD ID		03981	00423
Ensembl ID		ENSG00000184916	ENSG00000166165
Uniprot IDs		Q9Y219	A0A0S2Z471 P12277 V9HWH2
PDB IDs		5MW5 5MW7 5MWF	3B6R 3DRB 3DRE 6V9H 7BF1 7TUN
Enriched GO Terms of Interacting Partners?		Nuclear Matrix Cellular Response To Tumor Cell Notch Signaling Pathway Atrioventricular Node Development Glomerular Capillary Formation Artery Morphogenesis Negative Regulation Of Transcription By RNA Polymerase II Tube Morphogenesis Blood Vessel Morphogenesis Left/right Axis Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Pulmonary Valve Morphogenesis Morphogenesis Of An Epithelial Sheet Regulation Of Transcription By RNA Polymerase II Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of RNA Metabolic Process Renal Tubule Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Inflammatory Response To Antigenic Stimulus Neuron Projection Development Neuron Fate Commitment Receptor Complex Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Guidance Regulation Of Smooth Muscle Cell Differentiation Axon Guidance Regulation Of Ras Protein Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Semicircular Canal Formation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Heart Valve Morphogenesis Positive Regulation Of MiRNA Transcription Futile Creatine Cycle Transcription Coactivator Activity Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Abducens Nerve Formation Optokinetic Behavior Cardiac Muscle Tissue Development	Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Cellular Component Organization Cul5-RING Ubiquitin Ligase Complex Telomere Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Modification Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of Protein Localization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Regulation Of Cellular Component Organization Organelle Organization Intracellular Signal Transduction Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of DNA Metabolic Process
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