CKB and ASB9

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		CKB	ASB9
Description		creatine kinase B	ankyrin repeat and SOCS box containing 9
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Extracellular Exosome	Mitochondrion Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ubiquitin Protein Ligase Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Substantia Nigra Development Phosphocreatine Biosynthetic Process Futile Creatine Cycle	Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process
Pathways		Creatine metabolism RND3 GTPase cycle	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Creatine Phosphocreatine
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Height ( 28552196 31562340) Schizophrenia ( 25056061)	Metabolite levels ( 23823483)
Interacting Genes		29 interacting genes: ACD ARIH2 ASB9 CKM CUL5 DIO3 DNAH5 EML1 ERBB2 EVL FUT8 GOLGA2 GPR65 IFI27 ILK JAG2 MLH1 OGT POT1 PPP1CA PSEN1 SERP2 SMG5 SNCA TAB1 TERF1 TINF2 TRIM63 UBE3A	11 interacting genes: ACTN3 ASB13 CKB CKMT1A CKMT1B EXOSC1 HIF1AN LCK PLCG2 RELA UBE2D1
Entrez ID		1152	140462
HPRD ID		00423	06452
Ensembl ID		ENSG00000166165	ENSG00000102048
Uniprot IDs		A0A0S2Z471 P12277 V9HWH2	A0A024RBW7 Q96DX5
PDB IDs		3B6R 3DRB 3DRE 6V9H 7BF1 7TUN	3D9H 3ZKJ 3ZNG 6V9H
Enriched GO Terms of Interacting Partners?		Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Cellular Component Organization Cul5-RING Ubiquitin Ligase Complex Telomere Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Modification Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of Protein Localization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Regulation Of Cellular Component Organization Organelle Organization Intracellular Signal Transduction Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of DNA Metabolic Process	Phosphocreatine Biosynthetic Process Creatine Kinase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ankyrin Repeat Binding Positive Regulation Of T Cell Receptor Signaling Pathway Modified Amino Acid Metabolic Process Positive Regulation Of Antigen Receptor-mediated Signaling Pathway NF-kappaB Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Organophosphate Biosynthetic Process Positive Regulation Of Interleukin-12 Production Kinase Activity Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Release Of Sequestered Calcium Ion Into Cytosol Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Negative Regulation Of Sequestering Of Calcium Ion [protein]-asparagine 3-dioxygenase Activity Regulation Of Interleukin-12 Production Cytosol Platelet Activation Catalytic Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Futile Creatine Cycle ATP Binding Immune Response-activating Signaling Pathway NF-kappaB P50/p65 Complex Peptidyl-aspartic Acid 3-dioxygenase Activity Calcium Ion Transmembrane Import Into Cytosol Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Interleukin-6 Production Positive Regulation Of Bone Mineralization Involved In Bone Maturation Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Peptidyl-histidine Dioxygenase Activity Organophosphate Metabolic Process Immune Response-regulating Signaling Pathway Activation Of Immune Response T Cell Receptor Signaling Pathway
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