CKB and DNAH5

		CKB	DNAH5
Description		creatine kinase B	dynein axonemal heavy chain 5
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Outer Dynein Arm Cell Projection Glial Cell Projection 9+0 Motile Cilium 9+2 Motile Cilium
	Molecular Function	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ubiquitin Protein Ligase Binding	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Substantia Nigra Development Phosphocreatine Biosynthetic Process Futile Creatine Cycle	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Lateral Ventricle Development Flagellated Sperm Motility Outer Dynein Arm Assembly Establishment Of Localization In Cell Cilium Assembly Cilium Movement Involved In Cell Motility
Pathways		Creatine metabolism RND3 GTPase cycle
Drugs		Creatine Phosphocreatine
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Height ( 28552196 31562340) Schizophrenia ( 25056061)	Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Coffee consumption ( 29367735) Cognitive function in longevity ( 33607172) Corneal astigmatism ( 23322567) Emphysema imaging phenotypes ( 26030696) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) IgE grass sensitization ( 22036096) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Subclinical atherosclerosis traits (other) ( 17903303) Thyroid volume in Hashimoto’s thyroiditis ( 32019955) Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event) ( 27515689) Visceral fat ( 22589738)
Interacting Genes		29 interacting genes: ACD ARIH2 ASB9 CKM CUL5 DIO3 DNAH5 EML1 ERBB2 EVL FUT8 GOLGA2 GPR65 IFI27 ILK JAG2 MLH1 OGT POT1 PPP1CA PSEN1 SERP2 SMG5 SNCA TAB1 TERF1 TINF2 TRIM63 UBE3A	15 interacting genes: CDH6 CKB CTNND2 DAP LARGE1 MARCHF6 MICAL1 MTDH MVP MYO10 RAN RBFOX2 TLE1 TRIO USP7
Entrez ID		1152	1767
HPRD ID		00423	04514
Ensembl ID		ENSG00000166165	ENSG00000039139
Uniprot IDs		A0A0S2Z471 P12277 V9HWH2	Q8TE73
PDB IDs		3B6R 3DRB 3DRE 6V9H 7BF1 7TUN	8J07
Enriched GO Terms of Interacting Partners?		Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Cellular Component Organization Cul5-RING Ubiquitin Ligase Complex Telomere Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Modification Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of Protein Localization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Regulation Of Cellular Component Organization Organelle Organization Intracellular Signal Transduction Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of DNA Metabolic Process	Signal Transduction
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