IL12B and IL12RB1

Number of citations of the paper that reports this interaction (PubMedID 7527811)
0

Data Source:
HPRD (in vitro, in vivo)

		IL12B	IL12RB1
Description		interleukin 12B	interleukin 12 receptor subunit beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cytosol Cell Surface Membrane Endosome Lumen Late Endosome Lumen Interleukin-12 Complex Interleukin-23 Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Cytokine Receptor Binding Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Alpha Subunit Binding Identical Protein Binding Protein-containing Complex Binding Interleukin-23 Receptor Binding Protein Heterodimerization Activity	Cytokine Receptor Activity Interleukin-12 Receptor Binding Coreceptor Activity Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Natural Killer Cell Activation Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Response To UV-B Cell Migration Natural Killer Cell Activation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway T-helper 1 Type Immune Response T-helper Cell Differentiation T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation T Cell Activation Defense Response To Protozoan Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Oocyte Development Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Cellular Response To Type II Interferon Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs		5-Mercapto-2-Nitro-Benzoic Acid Briakinumab Ustekinumab Ustekinumab humanized SMART Anti-IL-12 Antibody Tildrakizumab Risankizumab
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency	IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Ankylosing spondylitis ( 23749187 21743469) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 32581322 17554261 20570966 30500874 21102463 28067908) Cutaneous psoriasis ( 26626624) Inflammatory bowel disease ( 26278503 23128233 28067908) interleukin 12 receptor subunit beta-1 levels ( 25147954) Leprosy ( 25642632 32421744) Multiple sclerosis ( 22190364 21833088) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761 25903422 19169254 23143594 19169255 20953190 20953188) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Response to taxane treatment (paclitaxel) ( 23006423) Sarcoidosis ( 26051272) Serum sulfate level ( 27412988) Takayasu arteritis ( 23830517 33308445) Tuberculosis susceptibility in HIV infection ( 26942285) Ulcerative colitis ( 28067908 21297633)	Mental health study participation (completed survey) ( 31263887) Pulmonary function in asthmatics ( 23541324) Systemic sclerosis ( 30572963 31672989) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: IL12A IL12RB1 IL12RB2	8 interacting genes: BRD4 CFTR IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4
Entrez ID		3593	3594
HPRD ID		01194	03363
Ensembl ID		ENSG00000113302	ENSG00000096996
Uniprot IDs		P29460	P42701
PDB IDs		1F42 1F45 3D85 3D87 3DUH 3HMX 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD 6UIB 6WDQ 8CR8 8OE4 8XRP 8YI7	6WDP 6WDQ 8C7M 8ODX 8OE4 8XRP 8YI7
Enriched GO Terms of Interacting Partners?		Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation T-helper Cell Differentiation T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Alpha-beta T Cell Differentiation T Cell Activation Involved In Immune Response Positive Regulation Of Type II Interferon Production Interleukin-12 Receptor Binding Alpha-beta T Cell Activation Regulation Of Type II Interferon Production Lymphocyte Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response T Cell Differentiation Cell Activation Involved In Immune Response Lymphocyte Differentiation T Cell Activation Mononuclear Cell Differentiation Leukocyte Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Immune Effector Process Cytokine-mediated Signaling Pathway Cytokine Binding Lymphocyte Activation Regulation Of T Cell Mediated Cytotoxicity Cytokine Receptor Activity Positive Regulation Of Cytokine Production Leukocyte Activation Coreceptor Activity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cell Activation Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Cytokine Production Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Population Proliferation Regulation Of Alpha-beta T Cell Activation Interleukin-12 Beta Subunit Binding Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Interleukin-27 Binding Positive Regulation Of Lymphocyte Mediated Immunity Interleukin-12 Receptor Activity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Interleukin-12 Complex	Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Interleukin-12-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Regulation Of T-helper Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Memory T Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production T-helper 1 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of T Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Interleukin-23 Receptor Binding Interleukin-23 Complex Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of Natural Killer Cell Activation Positive Regulation Of Interleukin-12 Production T Cell Differentiation Involved In Immune Response Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity
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