IL12RB1 and IL23R

Number of citations of the paper that reports this interaction (PubMedID 12023369)
0

Data Source:
HPRD (in vitro, in vivo)

		IL12RB1	IL23R
Description		interleukin 12 receptor subunit beta 1	interleukin 23 receptor
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Coreceptor Activity Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	Cytokine Receptor Activity Prolactin Receptor Activity Interleukin-12 Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Cellular Response To Type II Interferon Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Type II Interferon Interleukin-23-mediated Signaling Pathway Prolactin Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency	Crohn's disease
GWAS		Mental health study participation (completed survey) ( 31263887) Pulmonary function in asthmatics ( 23541324) Systemic sclerosis ( 30572963 31672989) Waist circumference adjusted for body mass index ( 34021172)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 21743469 23749187 20062062) Behcet's disease ( 33393726 20622879 20622878) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23850713 28067908 22936669 30500874 32581322 22412388 22293688 17447842 17435756 21102463 17554300 20570966 17804789 18587394) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233 28067908 18758464 28008999) Inflammatory skin disease ( 25574825) Leprosy ( 22019778 25642632) Pediatric autoimmune diseases ( 26301688) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Psoriasis ( 25903422 20953190 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Sarcoidosis ( 26051272 32826979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 19122664 19915572 28067908 20228799 26398853 32072174 21297633) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		8 interacting genes: BRD4 CFTR IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4	5 interacting genes: C1D IL12RB1 IL23A JAK2 STAT3
Entrez ID		3594	149233
HPRD ID		03363	16249
Ensembl ID		ENSG00000096996	ENSG00000162594
Uniprot IDs		P42701	Q5VWK5
PDB IDs		6WDP 6WDQ 8C7M 8ODX 8OE4 8XRP 8YI7	5MZV 6WDQ 8OE4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Interleukin-12-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Regulation Of T-helper Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Memory T Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production T-helper 1 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of T Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Interleukin-23 Receptor Binding Interleukin-23 Complex Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of Natural Killer Cell Activation Positive Regulation Of Interleukin-12 Production T Cell Differentiation Involved In Immune Response Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity	Interleukin-23-mediated Signaling Pathway Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of T-helper 17 Type Immune Response Interleukin-12 Receptor Complex Positive Regulation Of Skeletal Muscle Cell Proliferation Interleukin-23 Receptor Complex Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Type II Interferon Production Interleukin-12 Receptor Binding Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T Cell Proliferation Interleukin-12-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of NK T Cell Activation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Type II Interferon Production Positive Regulation Of Cytokine Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Cell Fate Commitment Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Skeletal Muscle Cell Proliferation T-helper 1 Cell Differentiation Interleukin-6-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of T-helper 1 Type Immune Response Regulation Of Tumor Necrosis Factor Production Regulation Of T Cell Proliferation Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Growth Hormone Receptor Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Adaptive Immune Response Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-17 Production
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