IL12RB1

Description		interleukin 12 receptor subunit beta 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Coreceptor Activity Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Cellular Response To Type II Interferon Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Mental health study participation (completed survey) ( 31263887) Pulmonary function in asthmatics ( 23541324) Systemic sclerosis ( 30572963 31672989) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		8 novel interacting genes: BRD4 CFTR IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4
Interacting Genes		8 interacting genes: BRD4 CFTR IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4
Entrez ID		3594
HPRD ID		03363
Ensembl ID		ENSG00000096996
Uniprot IDs		P42701
PDB IDs		6WDP 6WDQ 8C7M 8ODX 8OE4 8XRP 8YI7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Interleukin-12-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Regulation Of T-helper Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Memory T Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production T-helper 1 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of T Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Interleukin-23 Receptor Binding Interleukin-23 Complex Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of Natural Killer Cell Activation Positive Regulation Of Interleukin-12 Production T Cell Differentiation Involved In Immune Response Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity
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