PADI6 and KLHL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PADI6	KLHL2
Description		peptidyl arginine deiminase 6	kelch like family member 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoplasmic Vesicle Intermediate Filament Cytoskeleton Cortical Granule Cytoplasmic Lattice Ooplasm	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Tubulin Binding Identical Protein Binding Structural Constituent Of Cytoplasmic Lattice	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	In Utero Embryonic Development Cytoskeleton Organization Cytoplasm Organization Intracellular Protein Localization Embryonic Cleavage Regulation Of Translation By Machinery Localization Epigenetic Programming In The Zygotic Pronuclei Protein Storage	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Chromatin modifying enzymes	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Citrulline
Diseases
GWAS		Basal cell carcinoma ( 18849993 24403052 25855136) Mean platelet volume ( 27863252)	Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		3 interacting genes: KLHL2 SUV39H1 ZNF526	30 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA FRAS1 KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		353238	11275
HPRD ID		15095	09311
Ensembl ID		ENSG00000276747	ENSG00000109466
Uniprot IDs		Q6TGC4	B4DFZ5 E9PEX9 O95198
PDB IDs		4DAT 4DAU 8QL0 9FMN	2XN4 4CHB
Enriched GO Terms of Interacting Partners?		Nuclear Lamina Histone H3K9 Trimethyltransferase Activity Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Histone H3K9 Methyltransferase Activity RDNA Heterochromatin Formation ENoSc Complex RDNA Heterochromatin Facultative Heterochromatin Formation Epigenetic Programming In The Zygotic Pronuclei Chromatin Silencing Complex S-adenosylmethionine-dependent Methyltransferase Activity Blastocyst Hatching Histone H3 Methyltransferase Activity	Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis
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