IGHG1

Description		immunoglobulin heavy constant gamma 1 (G1m marker)
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome IgG Immunoglobulin Complex Blood Microparticle
	Molecular Function	Antigen Binding Protein Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Adaptive Immune Response Immune System Process Complement Activation, Classical Pathway Antibacterial Humoral Response B Cell Receptor Signaling Pathway Complement-dependent Cytotoxicity
Pathways
Drugs
Diseases
GWAS		Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)
Novel Interacting Genes		9 novel interacting genes: CD40LG CRYAA FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5 USP7
Interacting Genes		9 interacting genes: CD40LG CRYAA FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5 USP7
Entrez ID		3500
HPRD ID		11755
Ensembl ID		ENSG00000211896
Uniprot IDs
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Effector Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity IgG Receptor Activity Antibody-dependent Cellular Cytotoxicity Hypersensitivity IgG Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Regulation Of Immune System Process Leukocyte Mediated Immunity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Regulation Of DNA-binding Transcription Factor Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Inflammatory Response Immune System Process Somatic Recombination Of Immunoglobulin Gene Segments Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immune Response Response To Stress DNA Recombination Somatic Diversification Of Immunoglobulins Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process DNA Metabolic Process Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Adaptive Immune Response Acute Inflammatory Response Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process B Cell Activation Involved In Immune Response External Side Of Plasma Membrane Leukocyte Mediated Cytotoxicity Regulation Of Protein Stability Negative Regulation Of Proteolysis Involved In Protein Catabolic Process CD40 Receptor Binding Regulation Of Immune Response Immune Response-regulating Signaling Pathway Low-affinity IgG Receptor Activity Immune Receptor Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Autophagosome Assembly Protein Deubiquitination Positive Regulation Of Immune System Process Autophagosome Organization
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