IGHG1 and SWAP70

Number of citations of the paper that reports this interaction (PubMedID 10681448)
20

Data Source:
HPRD (in vitro)

		IGHG1	SWAP70
Description		immunoglobulin heavy constant gamma 1 (G1m marker)	switching B cell complex subunit SWAP70
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome IgG Immunoglobulin Complex Blood Microparticle	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Lamellipodium Cell Projection Postsynapse
	Molecular Function	Antigen Binding Protein Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding ATP Binding Cadherin Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Adaptive Immune Response Immune System Process Complement Activation, Classical Pathway Antibacterial Humoral Response B Cell Receptor Signaling Pathway Complement-dependent Cytotoxicity	Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Actin Polymerization Or Depolymerization Somatic Cell DNA Recombination Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Isotype Switching Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Mast Cell Chemotaxis
Pathways			RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)	Blood protein levels ( 30072576) Coronary artery disease ( 26343387 33020668 32469254 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 30487518 30224653 28739976) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 30578418 27841878 30487518) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: CD40LG CRYAA FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5 USP7	5 interacting genes: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5
Entrez ID		3500	23075
HPRD ID		11755	10378
Ensembl ID		ENSG00000211896	ENSG00000133789
Uniprot IDs			B3KUB9 E7EMB1 Q9UH65
PDB IDs			2DN6
Enriched GO Terms of Interacting Partners?		Immune Effector Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity IgG Receptor Activity Antibody-dependent Cellular Cytotoxicity Hypersensitivity IgG Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Regulation Of Immune System Process Leukocyte Mediated Immunity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Regulation Of DNA-binding Transcription Factor Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Inflammatory Response Immune System Process Somatic Recombination Of Immunoglobulin Gene Segments Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immune Response Response To Stress DNA Recombination Somatic Diversification Of Immunoglobulins Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process DNA Metabolic Process Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Adaptive Immune Response Acute Inflammatory Response Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process B Cell Activation Involved In Immune Response External Side Of Plasma Membrane Leukocyte Mediated Cytotoxicity Regulation Of Protein Stability Negative Regulation Of Proteolysis Involved In Protein Catabolic Process CD40 Receptor Binding Regulation Of Immune Response Immune Response-regulating Signaling Pathway Low-affinity IgG Receptor Activity Immune Receptor Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Autophagosome Assembly Protein Deubiquitination Positive Regulation Of Immune System Process Autophagosome Organization	NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity DNA ADP-ribosylation Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of ATP Biosynthetic Process NAD+-protein-serine ADP-ribosyltransferase Activity NAD DNA ADP-ribosyltransferase Activity Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Regulation Of Base-excision Repair ATP Generation From Poly-ADP-D-ribose Transcription Pausing By RNA Polymerase II Replication Fork Reversal Positive Regulation Of Necroptotic Process Mitochondrial DNA Repair Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Adipose Tissue Development Antibody-dependent Cellular Cytotoxicity Immunoglobulin Complex, Circulating Regulation Of Myofibroblast Differentiation Positive Regulation Of Mitochondrial Depolarization IgG Immunoglobulin Complex Immune Response Protein Auto-ADP-ribosylation Positive Regulation Of Programmed Necrotic Cell Death Transcription Regulator Activator Activity Adaptive Immune Response Hypersensitivity NAD+-protein-glutamate ADP-ribosyltransferase Activity Positive Regulation Of Membrane Depolarization Positive Regulation Of Adipose Tissue Development NAD+-protein-aspartate ADP-ribosyltransferase Activity
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