ANKRD13D and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 33665565)
71

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ANKRD13D	NEDD8
Description		ankyrin repeat domain 13D	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Cytoplasm Endosome Late Endosome Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Ubiquitin-modified Protein Reader Activity	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Receptor Internalization	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly
Pathways			TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		11 interacting genes: APP MFHAS1 MTDH NEDD4 NEDD8 NID2 SMURF1 TNFAIP3 UBC UBQLN4 WBP2	72 interacting genes: AHR ANKRD13D ARIH2 ATE1 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		338692	4738
HPRD ID		17349	04412
Ensembl ID		ENSG00000172932	ENSG00000129559
Uniprot IDs		Q6ZTN6	Q15843
PDB IDs		7RMA	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Modification-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Progesterone Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Proteolysis Protein Tag Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Establishment Of Protein Localization To Organelle Regulation Of Protein Catabolic Process Receptor Catabolic Process Regulation Of Proteolysis Extracellular Exosome Post-translational Protein Modification Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Receptor Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Receptor Metabolic Process Protein Targeting To Vacuole Ubiquitin-protein Transferase Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Formation Of Structure Involved In A Symbiotic Process Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Engulfment Of Target By Autophagosome Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Protein Metabolic Process Perinuclear Region Of Cytoplasm Regulation Of Synapse Organization	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm
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