NEDD8 and OTUD6B

Number of citations of the paper that reports this interaction (PubMedID 33665565)
71

Data Source:
BioGRID (pull down)

		NEDD8	OTUD6B
Description		NEDD8 ubiquitin like modifier	OTU deubiquitinase 6B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse	Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly	Proteolysis Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Translation Proteasome Assembly Positive Regulation Of Translation
Pathways		TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		72 interacting genes: AHR ANKRD13D ARIH2 ATE1 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2	6 interacting genes: LIN28B NEDD8 OTUB1 SMURF1 UBC VHL
Entrez ID		4738	51633
HPRD ID		04412	13041
Ensembl ID		ENSG00000129559	ENSG00000155100
Uniprot IDs		Q15843	A0A087X0W9 Q8N6M0
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm	Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Catabolic Process Proteolysis Protein Tag Activity Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Binding Nucleoplasm Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Engulfment Of Target By Autophagosome Negative Regulation Of TOR Signaling Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Regulation Of TORC1 Signaling Protein Metabolic Process Protein Catabolic Process Cytosol Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Pre-miRNA Processing Regulation Of TOR Signaling Cellular Response To Camptothecin Ubiquitin-protein Transferase Inhibitor Activity DeNEDDylase Activity Activin Receptor Binding Positive Regulation Of MiRNA Catabolic Process Extracellular Exosome Transcription Elongation Factor Activity Substrate Localization To Autophagosome Negative Regulation Of MiRNA Processing Ubiquitin-protein Transferase Activity MiRNA Catabolic Process Cytoplasm I-SMAD Binding Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Negative Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Binding Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Pre-miRNA Processing Regulation Of Regulatory NcRNA Processing Receptor Catabolic Process Regulation Of Proteolysis
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