ANKRD13D and NID2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANKRD13D	NID2
Description		ankyrin repeat domain 13D	nidogen 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Late Endosome Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Basement Membrane Extracellular Space Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin-modified Protein Reader Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding
	Biological Process	Negative Regulation Of Receptor Internalization	Cell Adhesion Cell-matrix Adhesion Basement Membrane Organization
Pathways			Laminin interactions Laminin interactions
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Age-related hearing impairment ( 34108613) Apolipoprotein A1 levels ( 32203549) Body mass index ( 28892062) Craniofacial microsomia ( 26853712) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Lung cancer (smoking interaction) ( 24658283) Pulmonary function ( 17903307) Triglyceride levels ( 32203549 29403010) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 26785701) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		11 interacting genes: APP MFHAS1 MTDH NEDD4 NEDD8 NID2 SMURF1 TNFAIP3 UBC UBQLN4 WBP2	27 interacting genes: ANKRD13D CCN3 COL13A1 COL1A1 COL4A1 ELN GNE HOXC8 HSPG2 KCNJ1 KPRP KRTAP1-3 KRTAP10-3 KRTAP6-2 LAMC1 LCE1A MAML3 PITX1 PLSCR4 POLE2 RBP3 SKIL TFG TNFRSF14 UNKL ZNF581 ZNF774
Entrez ID		338692	22795
HPRD ID		17349	05654
Ensembl ID		ENSG00000172932	ENSG00000087303
Uniprot IDs		Q6ZTN6	Q14112
PDB IDs		7RMA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Modification-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Progesterone Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Proteolysis Protein Tag Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Establishment Of Protein Localization To Organelle Regulation Of Protein Catabolic Process Receptor Catabolic Process Regulation Of Proteolysis Extracellular Exosome Post-translational Protein Modification Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Receptor Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Receptor Metabolic Process Protein Targeting To Vacuole Ubiquitin-protein Transferase Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Formation Of Structure Involved In A Symbiotic Process Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Engulfment Of Target By Autophagosome Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Protein Metabolic Process Perinuclear Region Of Cytoplasm Regulation Of Synapse Organization	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Structural Constituent Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Tissue Development Platelet-derived Growth Factor Binding Extracellular Matrix Constituent Conferring Elasticity Skeletal Muscle Tissue Development Collagen Trimer Collagen-activated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Circulatory System Development
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