HOXC9 and GMNN

Number of citations of the paper that reports this interaction (PubMedID 14973489)
0

Data Source:
HPRD (in vitro)

		HOXC9	GMNN
Description		homeobox C9	geminin DNA replication inhibitor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Aggresome Transcription Repressor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Negative Regulation Of Cell Cycle Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication
Pathways			Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		A body shape index ( 34021172) Heel bone mineral density ( 30598549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Metabolite levels ( 23823483)
Interacting Genes		29 interacting genes: CBX6 CYSRT1 ELAVL2 GMNN GTF2A1L HOXC13 HOXD1 HOXD9 IRF9 KRTAP6-2 LPXN MAGED1 MSX2 NFKBID NMI PAX6 PAX8 PBX2 PCGF2 POLR2D POLR3D POU2AF1 POU2F1 SPMIP9 TLE5 UFSP1 ZFP36 ZMYND12 ZNF384	35 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SHANK2 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		3225	51053
HPRD ID		00857	06783
Ensembl ID		ENSG00000180806	ENSG00000112312
Uniprot IDs		P31274	O75496
PDB IDs		2LP0 2MSY	1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regionalization Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Pattern Specification Process Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Anterior/posterior Pattern Specification DNA-binding Transcription Factor Activity Chromatin Binding Animal Organ Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Embryonic Morphogenesis Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Metabolic Process Embryonic Skeletal System Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal System Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Embryonic Limb Morphogenesis PRC1 Complex Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process	Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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