GMNN and HOXC8

Number of citations of the paper that reports this interaction (PubMedID 14973489)
0

Data Source:
HPRD (in vitro)

		GMNN	HOXC8
Description		geminin DNA replication inhibitor	homeobox C8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Neuron Differentiation Skeletal System Morphogenesis
Pathways		Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		35 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SHANK2 SIX3 SMARCA4 ZNF250 ZNF439	108 interacting genes: ACTMAP ADAMTSL4 AIRIM ANKS1A BLZF1 BMPR1A BTG2 CADPS CCM2 CEP70 CFAP68 CRYBA1 CYSRT1 DLX2 DLX5 DVL3 DZIP3 ECM1 FNTB GMNN GOLGA6L9 GSTO2 GYS1 HESX1 HOMEZ HOXD3 HSF2BP IKZF3 JUN KCTD9 KHDC1 KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-3 KRTAP19-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LDLRAP1 LDOC1 LHX2 LHX3 LRP2BP MAPK8IP2 MEOX1 MEOX2 METTL15 MGAT5B MSX1 NADSYN1 NBPF19 NFKBID NID2 NOTCH2NLA OIP5 PAX5 PAX6 PAX8 PBX1 PBX2 PBX4 PDE4DIP PFDN5 PLA2G10 PLEKHG4 POU2AF1 POU6F2 PPARA PRDM14 PRDM6 RBCK1 RBPMS SLAIN1 SMAD1 SMAD4 SMAD6 SNX17 TBC1D1 TBX19 TBX22 TEKT4 TLE5 TNS2 TRAF1 TRIB3 TRIM27 TRIM42 TRIP6 TSC1 USP54 VENTX WWOX ZFP90 ZMAT5 ZNF34 ZRANB1
Entrez ID		51053	3224
HPRD ID		06783	00856
Ensembl ID		ENSG00000112312	ENSG00000037965
Uniprot IDs		O75496	P31273
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Intermediate Filament Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Pituitary Gland Development Positive Regulation Of RNA Metabolic Process Regionalization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SMAD Protein Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Gland Development Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Sensory Organ Development Animal Organ Development Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Transcription Cis-regulatory Region Binding Epithelial Cell Differentiation DNA Binding Heteromeric SMAD Protein Complex Cell Fate Specification BMP Signaling Pathway Sequence-specific Double-stranded DNA Binding Epithelium Development R-SMAD Binding Cell Differentiation Embryonic Pattern Specification
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