GMNN and HOXA7

Number of citations of the paper that reports this interaction (PubMedID 14973489)
0

Data Source:
HPRD (in vitro)

		GMNN	HOXA7
Description		geminin DNA replication inhibitor	homeobox A7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex	Chromatin Nucleus Nucleoplasm Nuclear Membrane
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Leukocyte Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Stem Cell Differentiation
Pathways		Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		35 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SHANK2 SIX3 SMARCA4 ZNF250 ZNF439	6 interacting genes: GMNN JUNB MEIS1 NPM1 PEX5 SDCBP
Entrez ID		51053	3204
HPRD ID		06783	00838
Ensembl ID		ENSG00000112312	ENSG00000122592
Uniprot IDs		O75496	P31268
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Osteoclast Proliferation Regulation Of RNA Biosynthetic Process Transcription Factor AP-1 Complex Regulation Of Cell Cycle Myeloid Leukocyte Differentiation Chromatin Binding Negative Regulation Of Cellular Component Organization Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Regulation Of Growth Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Regulation Of Endoribonuclease Activity Protein-DNA Complex Assembly Ribosomal Large Subunit Export From Nucleus DNA-binding Transcription Factor Binding Positive Regulation Of Centrosome Duplication Granular Component Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Membrane Establishment Of Protein Localization To Membrane Peroxisome Membrane Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Regulation Of Extracellular Exosome Assembly Syndecan Binding Positive Regulation Of Chromatin Binding DNA Replication Preinitiation Complex Assembly Positive Regulation Of Cell Population Proliferation Embryonic Process Involved In Female Pregnancy Transcription Regulator Complex Myeloid Cell Differentiation Cell Growth Involved In Cardiac Muscle Cell Development Tat Protein Binding Regulation Of Organelle Assembly Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling
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