CERS2 and SLC19A2

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CERS2	SLC19A2
Description		ceramide synthase 2	solute carrier family 19 member 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Transferase Activity Sphingosine N-acyltransferase Activity	Protein Binding Folic Acid Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Vitamin Transmembrane Transporter Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Negative Regulation Of Schwann Cell Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Response To Immobilization Stress Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration	Spermatogenesis Thiamine Diphosphate Biosynthetic Process Folic Acid Transport Thiamine Transport Pyridoxine Transport Thiamine-containing Compound Metabolic Process Vitamin Transport Transmembrane Transport Thiamine Transmembrane Transport
Pathways		Sphingolipid de novo biosynthesis	Vitamin B1 (thiamin) metabolism
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Estimated glomerular filtration rate ( 31015462 31152163) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)	Plasma factor V levels in venous thrombosis ( 31271701) Venous thromboembolism ( 21980494)
Interacting Genes		16 interacting genes: ASGR1 ASGR2 ATP6V0C CERS6 DRD2 HSP90AA1 IER3IP1 NFE2L2 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 TNFSF4 UBC YIF1A	3 interacting genes: CERS2 DEDD SC5D
Entrez ID		29956	10560
HPRD ID		06080	04897
Ensembl ID		ENSG00000143418	ENSG00000117479
Uniprot IDs		Q96G23	A0A024R8Y5 A0A024R928 O60779
PDB IDs			8Z7Z 8Z80
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Response To Hypoxia Asialoglycoprotein Receptor Activity Regulation Of Cellular Response To Hypoxia Transmembrane Transport Ubiquitin Protein Ligase Binding Thiamine Transmembrane Transporter Activity Thiamine Transport Thiamine Transmembrane Transport Membrane Fucose Binding Catecholamine Uptake Dopamine Uptake Protein Unfolding Azole Transmembrane Transport Plasma Membrane Pyrimidine-containing Compound Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Vitamin Transmembrane Transport Dopamine Transport Neurotransmitter Reuptake D-mannose Binding Monoatomic Cation Transmembrane Transport Endoplasmic Reticulum Membrane Establishment Of Localization In Cell Monoamine Transport Neurotransmitter Uptake Organic Hydroxy Compound Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport COPII-coated ER To Golgi Transport Vesicle Pattern Recognition Receptor Activity Response To Cocaine Vitamin Transport CTP Binding DATP Binding Positive Regulation Of Glutathione Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Monoatomic Ion Transport Lateral Plasma Membrane G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Carboxylic Acid Transport Organic Acid Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding	Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Sphingosine N-acyltransferase Activity Negative Regulation Of Glial Cell Migration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Ferroptosis Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Regulation Of Ferroptosis Lipid Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration Response To Immobilization Stress Decidualization Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Cholesterol Biosynthetic Process Sterol Biosynthetic Process Regulation Of Transcription By RNA Polymerase I Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Ceramide Biosynthetic Process Endoplasmic Reticulum Membrane Lipid Metabolic Process
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