CERS2 and CERS6

Number of citations of the paper that reports this interaction (PubMedID 24706805)
34

Data Source:
BioGRID (pull down)

		CERS2	CERS6
Description		ceramide synthase 2	ceramide synthase 6
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Transferase Activity Sphingosine N-acyltransferase Activity	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Negative Regulation Of Schwann Cell Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Response To Immobilization Stress Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration	Lipid Metabolic Process Sphingolipid Metabolic Process Inflammatory Response Oligodendrocyte Development Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways		Sphingolipid de novo biosynthesis	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Estimated glomerular filtration rate ( 31015462 31152163) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)	Bipolar disorder ( 31043756 34002096) Parkinson's disease ( 27182965) Recurrent major depressive disorder ( 34099189) Recurrent major depressive disorder x sex interaction ( 34099189) Red cell distribution width ( 27863252 28957414 32888494) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		16 interacting genes: ASGR1 ASGR2 ATP6V0C CERS6 DRD2 HSP90AA1 IER3IP1 NFE2L2 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 TNFSF4 UBC YIF1A	5 interacting genes: AGTR1 BCL2L13 CERS2 OPRL1 SEC22B
Entrez ID		29956	253782
HPRD ID		06080	17258
Ensembl ID		ENSG00000143418	ENSG00000172292
Uniprot IDs		Q96G23	Q6ZMG9
PDB IDs			8QZ6 8QZ7 9EOT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Response To Hypoxia Asialoglycoprotein Receptor Activity Regulation Of Cellular Response To Hypoxia Transmembrane Transport Ubiquitin Protein Ligase Binding Thiamine Transmembrane Transporter Activity Thiamine Transport Thiamine Transmembrane Transport Membrane Fucose Binding Catecholamine Uptake Dopamine Uptake Protein Unfolding Azole Transmembrane Transport Plasma Membrane Pyrimidine-containing Compound Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Vitamin Transmembrane Transport Dopamine Transport Neurotransmitter Reuptake D-mannose Binding Monoatomic Cation Transmembrane Transport Endoplasmic Reticulum Membrane Establishment Of Localization In Cell Monoamine Transport Neurotransmitter Uptake Organic Hydroxy Compound Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport COPII-coated ER To Golgi Transport Vesicle Pattern Recognition Receptor Activity Response To Cocaine Vitamin Transport CTP Binding DATP Binding Positive Regulation Of Glutathione Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Monoatomic Ion Transport Lateral Plasma Membrane G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Carboxylic Acid Transport Organic Acid Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Angiotensin Type I Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Nociceptin Receptor Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin G Protein-coupled Opioid Receptor Activity Negative Regulation Of Glial Cell Migration Sphingosine N-acyltransferase Activity Regulation Of Lipid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Renal Sodium Excretion Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Autophagosome Assembly Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Neuron Projection Regeneration G Protein-coupled Receptor Activity Low-density Lipoprotein Particle Remodeling Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Through Glucose-6-phosphate Oxidative Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration
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