DPP7 and NPHP3

		DPP7	NPHP3
Description		dipeptidyl peptidase 7	nephrocystin 3
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GO Annotations	Cellular Component	Extracellular Region Lysosome Golgi Apparatus Cytoplasmic Vesicle Vesicle Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Cytosol Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base
	Molecular Function	Aminopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Hydrolase Activity Serine-type Exopeptidase Activity	Protein Binding
	Biological Process	Proteolysis Lysosomal Protein Catabolic Process	Kidney Development Heart Looping Atrial Septum Development Lipid Metabolic Process Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Non-motile Cilium Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Neutrophil degranulation	Trafficking of myristoylated proteins to the cilium
Drugs
Diseases			Renal-hepatic-pancreatic dysplasia Meckel syndrome (MKS); Meckel-Gruber syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Pursuit maintenance gain ( 29064472)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 21102462 27182965) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: CFTR CSF2 ERGIC1 NPHP3 XRN1	18 interacting genes: ANAPC13 ASTE1 ATXN1 CCDC50 CDV3 COL7A1 DDX3Y DNAJC13 DPP7 DYSF EPC1 NAA50 NPHP1 PARP14 PIK3R4 PPP2R3A RAB6B TOPBP1
Entrez ID		29952	27031
HPRD ID		07634	06417
Ensembl ID		ENSG00000176978	ENSG00000113971
Uniprot IDs		Q9UHL4	Q7Z494
PDB IDs		3JYH 3N0T 4EBB	5L7K
Enriched GO Terms of Interacting Partners?		Epithelial Fluid Transport Fluid Transport Transepithelial Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Cellular Response To Puromycin Cellular Response To Cycloheximide Positive Regulation Of Anion Channel Activity Response To Purine-containing Compound Response To Lipid Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Response To Silicon Dioxide Maintenance Of Animal Organ Identity Ciliary Inversin Compartment 5'-3' RNA Exonuclease Activity Cellular Response To Oxygen-containing Compound Transepithelial Water Transport Determination Of Pancreatic Left/right Asymmetry Response To Cycloheximide Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Response To Ketone Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Interleukin-23 Production Histamine Secretion Ureter Development Determination Of Digestive Tract Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Response To Alcohol Neutrophil Differentiation G-quadruplex RNA Binding Amelogenesis Histamine Transport Atrial Septum Development G-quadruplex DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Interleukin-23 Production 5'-3' Exonuclease Activity	Double-strand Break Repair Via Nonhomologous End Joining
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