NPHP3 and CDV3

		NPHP3	CDV3
Description		nephrocystin 3	CDV3 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding
	Biological Process	Kidney Development Heart Looping Atrial Septum Development Lipid Metabolic Process Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Non-motile Cilium Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Trafficking of myristoylated proteins to the cilium
Drugs
Diseases		Renal-hepatic-pancreatic dysplasia Meckel syndrome (MKS); Meckel-Gruber syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 21102462 27182965) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)	Bulimia nervosa ( 23568457)
Interacting Genes		18 interacting genes: ANAPC13 ASTE1 ATXN1 CCDC50 CDV3 COL7A1 DDX3Y DNAJC13 DPP7 DYSF EPC1 NAA50 NPHP1 PARP14 PIK3R4 PPP2R3A RAB6B TOPBP1	1 interacting genes: NPHP3
Entrez ID		27031	55573
HPRD ID		06417	13627
Ensembl ID		ENSG00000113971	ENSG00000091527
Uniprot IDs		Q7Z494	A0A8I5KX85 D6R9V8 D6RDN0 D6RFH2 Q9UKY7
PDB IDs		5L7K
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Nonhomologous End Joining	Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Maintenance Of Animal Organ Identity Ureter Development Ciliary Inversin Compartment Determination Of Digestive Tract Left/right Asymmetry Determination Of Pancreatic Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Atrial Septum Development Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Convergent Extension Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Kidney Morphogenesis Regulation Of Non-canonical Wnt Signaling Pathway Epithelial Cilium Movement Involved In Extracellular Fluid Movement Cardiac Septum Development Extracellular Transport Photoreceptor Cell Maintenance Ciliary Base Non-motile Cilium Assembly Heart Looping Embryonic Heart Tube Morphogenesis Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Lung Development Epithelial Tube Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Kidney Development Cilium Movement Negative Regulation Of Wnt Signaling Pathway Establishment Or Maintenance Of Cell Polarity Tube Development Microtubule-based Transport Extracellular Matrix Organization Regulation Of Canonical Wnt Signaling Pathway Extracellular Structure Organization Cilium Assembly Wnt Signaling Pathway Tube Morphogenesis Cilium Organization Regulation Of Wnt Signaling Pathway Morphogenesis Of An Epithelium Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Pattern Specification Process Tissue Morphogenesis Microtubule-based Movement Embryonic Morphogenesis
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