GMPPA and DCUN1D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GMPPA	DCUN1D1
Description		GDP-mannose pyrophosphorylase A	defective in cullin neddylation 1 domain containing 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome GDP-mannose Pyrophosphorylase Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Mannose-1-phosphate Guanylyltransferase (GTP) Activity Enzyme Inhibitor Activity Protein Binding Transferase Activity Enzyme Binding Molecular Sensor Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Protein Glycosylation Glycoprotein Metabolic Process GDP-mannose Biosynthetic Process Negative Regulation Of Biosynthetic Process GDP-mannose Metabolic Process Telencephalon Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Muscle Organ Morphogenesis Cognition Neuromuscular Process Neuron Apoptotic Process Skeletal Muscle Organ Development Motor Behavior Negative Regulation Of Small Molecule Metabolic Process	Regulation Of Protein Ubiquitination Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		Synthesis of GDP-mannose	Neddylation
Drugs
Diseases
GWAS			Fasting insulin ( 34074324) Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		11 interacting genes: AKT1 BTC CDR2 CRP DCUN1D1 GMPPB GPKOW LSM8 NCK1 PNKD ZNF688	32 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B
Entrez ID		29926	54165
HPRD ID		13588	12067
Ensembl ID		ENSG00000144591	ENSG00000043093
Uniprot IDs		A0A384MDS7 Q96IJ6	B4DM76 C9JVE2 Q96GG9
PDB IDs		7D72 7D73 7D74	3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W 6XOL 6XOM 6XON 6XOO 6XOP 6XOQ 7KWA 8OR2 8OR3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process NEDD8 Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Midbody NEDD8 Transferase Activity Ubiquitin Ligase Complex Cleavage Furrow Formation Mitotic Spindle Assembly Macromolecule Catabolic Process Protein Targeting To Vacuole Innate Immune Response Negative Regulation Of Signal Transduction Protein Polyubiquitination Transferase Activity Establishment Of Protein Localization To Vacuole Proteolysis Spindle Midzone Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Mitotic Cytokinesis Cytosol Intrinsic Apoptotic Signaling Pathway Vesicle Protein K63-linked Ubiquitination Cul5-RING Ubiquitin Ligase Complex Endosome Defense Response To Symbiont Negative Regulation Of CGAS/STING Signaling Pathway Defense Response To Other Organism Protein Binding Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Cytokinesis Ubiquitin-like Protein Transferase Activity Spindle Assembly Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Protein Localization To Vacuole Protein Neddylation
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