GMPPA and PNKD

		GMPPA	PNKD
Description		GDP-mannose pyrophosphorylase A	PNKD metallo-beta-lactamase domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome GDP-mannose Pyrophosphorylase Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Presynaptic Cytosol
	Molecular Function	Mannose-1-phosphate Guanylyltransferase (GTP) Activity Enzyme Inhibitor Activity Protein Binding Transferase Activity Enzyme Binding Molecular Sensor Activity	Hydroxyacylglutathione Hydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Protein Glycosylation Glycoprotein Metabolic Process GDP-mannose Biosynthetic Process Negative Regulation Of Biosynthetic Process GDP-mannose Metabolic Process Telencephalon Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Muscle Organ Morphogenesis Cognition Neuromuscular Process Neuron Apoptotic Process Skeletal Muscle Organ Development Motor Behavior Negative Regulation Of Small Molecule Metabolic Process	Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Negative Regulation Of Neurotransmitter Secretion Neuromuscular Process Controlling Posture
Pathways		Synthesis of GDP-mannose
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS			Appendicular lean mass ( 33097823) Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Glycated hemoglobin levels ( 34059833) Granulocyte count ( 27863252) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) White blood cell count ( 27863252)
Interacting Genes		11 interacting genes: AKT1 BTC CDR2 CRP DCUN1D1 GMPPB GPKOW LSM8 NCK1 PNKD ZNF688	10 interacting genes: APP CNPPD1 ENO3 GMPPA KCTD9 KLHL20 MAGEA11 MYL12B SPEG UBC
Entrez ID		29926	25953
HPRD ID		13588	11369
Ensembl ID		ENSG00000144591	ENSG00000127838
Uniprot IDs		A0A384MDS7 Q96IJ6	Q8N490
PDB IDs		7D72 7D73 7D74
Enriched GO Terms of Interacting Partners?		Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response
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