STRN4 and MAP4K3

Number of citations of the paper that reports this interaction (PubMedID 32640226)
55

Data Source:
BioGRID (pull down)

		STRN4	MAP4K3
Description		striatin 4	mitogen-activated protein kinase kinase kinase kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite Protein-containing Complex Neuronal Cell Body Dendritic Spine FAR/SIN/STRIPAK Complex Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm
	Molecular Function	Protein Binding Calmodulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Hippo Signaling Regulation Of Modification Of Postsynaptic Structure	Protein Phosphorylation JNK Cascade Response To UV Response To Tumor Necrosis Factor Intracellular Signal Transduction
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Primary sclerosing cholangitis ( 23603763)	Bone mineral density ( 31790847)
Interacting Genes		28 interacting genes: AK5 ASNS CALM1 CAV1 CLDN12 CRK DDX39B DFFA ECSIT GDF9 JUN KLHDC2 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MIF MSANTD2 MTG1 NBEA PBDC1 PI4KA PLPPR3 PPBP SLC25A6 TNIK WIPI2 WNT7A	10 interacting genes: ACE2 BIN1 COPS5 HNRNPLL ITSN2 PPP2CA SH3GL2 SH3RF1 SORBS1 STRN4
Entrez ID		29888	8491
HPRD ID		18125	05373
Ensembl ID		ENSG00000090372	ENSG00000011566
Uniprot IDs		F5GYK2 Q59GV6 Q9NRL3	A8K602 B3KMM5 B4DSS3 F5H5A3 Q8IVH8
PDB IDs			5J5T
Enriched GO Terms of Interacting Partners?		MAP Kinase Kinase Kinase Kinase Activity MAPK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of JNK Cascade Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Kinase Activity Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Transforming Growth Factor Beta Stimulus Nucleotide Binding ATP Binding Response To Transforming Growth Factor Beta Protein Serine Kinase Activity Protein Phosphorylation Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Cytokine Activity Regulation Of Fibroblast Proliferation Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Junction Assembly Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Muscle Cell Action Potential	Presynaptic Endocytosis Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse FAR/SIN/STRIPAK Complex Endocytosis Negative Regulation Of Hippo Signaling Import Into Cell Vesicle-mediated Transport Tau Protein Binding Regulation Of Hippo Signaling Membrane Raft Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Contraction Negative Regulation Of Signal Transduction Regulation Of Cell Communication RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Signaling RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Negative Regulation Of Signaling Macrophage Migration Inhibitory Factor Binding Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Synapse Regulation Of Striated Muscle Contraction Negative Regulation Of Blood-brain Barrier Permeability Entry Receptor-mediated Virion Attachment To Host Cell Cytoplasm Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Exosomal Secretion Viral Translation Viral Life Cycle Regulation Of Macromolecule Metabolic Process Synaptic Vesicle Negative Regulation Of Cardiac Muscle Contraction Negative Regulation Of Action Potential Positive Regulation Of Cellular Component Biogenesis Regulation Of Generation Of Precursor Metabolites And Energy
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